| Catalog No. | Size | Price (USD) |
| 11039-T16-50 | 50 µL | $147.96 |
| 11039-T16-100 | 100 µL | $251.64 |
| 11039-T16-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-N-Cadherin Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human N-Cadherin |
| Immunogen | Recombinant Human N-Cadherin / CD325 / CDH2 Protein (Catalog#11039-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human N-Cadherin / CD325 / CDH2 (rh N-Cadherin / CD325 / CDH2; Catalog#11039-H08H; NP_001783.2; Met1-Ala724). N-Cadherin / CD325 / CDH2 specific IgG was purified by Human N-Cadherin / CD325 / CDH2 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ACOGS Antibody; Anti-ADHD8 Antibody; Anti-ARVD14 Antibody; Anti-CD325 Antibody; Anti-CDHN Antibody; Anti-CDw325 Antibody; Anti-NCAD Antibody
Background Information
| Full Name | cadherin 2, type 1, N-cadherin (neuronal) |
| Description | Cadherins are calcium-dependent cell adhesion proteins, and they preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin 2 (CDH2), also known as N-Cadherin (neuronal) (NCAD), is a single-pass transmembrane protein and a cadherin containing 5 cadherin domains. N-Cadherin displays a ubiquitous expression pattern but with different expression levels between endocrine cell types. CDH2 (NCAD) has been shown to play an essential role in normal neuronal development, which is implicated in an array of processes including neuronal differentiation and migration, and axon growth and fasciculation. In addition, N-Cadherin expression was upregulated in human HSC during activation in culture, and function or expression blocking of N-Cadherin promoted apoptosis. During apoptosis, N-Cadherin was cleaved into 20-100 kDa fragments. It may provide a novel target for therapies that are directed toward intimal proliferative disorders, including restenosis and vascular bypass graft failure. N-Cadherin is associated with tumor aggressiveness and metastatic potential and may contribute to tumor progression. |
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