| Catalog No. | Size | Price (USD) |
| 310320-T08-50 | 50 µL | $147.96 |
| 310320-T08-100 | 100 µL | $251.64 |
| 310320-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-B7-H2/ICOSLG Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human B7-H2/ICOSLG |
| Immunogen | E. coli-derived Human ICOS ligand fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human ICOS ligand fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-B7-H2 Antibody; Anti-B7h Antibody; Anti-B7H2 Antibody; Anti-B7RP-1 Antibody; Anti-B7RP1 Antibody; Anti-CD275 Antibody; Anti-GL50 Antibody; Anti-ICOS-L Antibody; Anti-ICOSL Antibody; Anti-IMD119 Antibody; Anti-KIAA0653 Antibody; Anti-LICOS Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human ICOS ligand in human liver with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human ICOS ligand Immunohistochemistry(IHC) 25220 |
| Image 1 URL | Source image |
Background Information
| Full Name | inducible T-cell co-stimulator ligand |
| Description | Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation. |
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