| Catalog No. | Size | Price (USD) |
| 310715-T08-50 | 50 µL | $147.96 |
| 310715-T08-100 | 100 µL | $251.64 |
| 310715-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-IL-23 P19/IL23A Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human IL-23 P19/IL23A |
| Immunogen | E. coli-derived Human IL-23 P19 / IL23A fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human IL-23 P19 / IL23A fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-IL-23 Antibody; Anti-IL-23A Antibody; Anti-IL23P19 Antibody; Anti-P19 Antibody; Anti-SGRF Antibody; Anti-UNQ2498/PRO5798 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human IL23A in human small intestine with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human IL-23 P19 / IL23A Immunohistochemistry(IHC) 29760 |
| Image 1 URL | Source image |
Background Information
| Full Name | interleukin 23, alpha subunit p19 |
| Description | IL-23, which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family, which includes IL-12, IL-27, and IL-35. IL-23 is a heterodimeric cytokine, comprised of a unique p19 subunit and p4 subunit, the latter of which is shared with IL-12. The receptor for IL-23 consists of IL-23R and IL-12Rβ1, the latter of which is also characteristic of IL-12. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling pathway. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis, primary biliary cirrhosis, and inflammatory bowel disease. |
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