Anti-IL-12 p40/IL12B Antibody, Mouse Monoclonal sinobiological 51004-MM01
$243.00
In stock
SKU
51004-MM01
| Catalog No. | Size | Price (USD) |
| 51004-MM01-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-IL-12 p40/IL12B Antibody, Mouse Monoclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse IL-12 p40/IL12B |
| Immunogen | Recombinant Mouse IL12B Protein (Catalog#51004-MCCH) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Mouse IL12B (rM IL12B; Catalog#51004-MCCH; P43432; Met1-Ser335). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Source | Monoclonal Mouse IgG1 Clone #01 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-Il-12b Antibody; Anti-Il-12p40 Antibody; Anti-Il12b Antibody; Anti-Il12p40 Antibody; Anti-p40 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of Mouse IL12B in Mouse spleen with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Mouse IL12B Immunohistochemistry(IHC) 37585 |
| Image 1 URL | Source image |
Background Information
| Full Name | interleukin 12B |
| Description | Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts on T and natural killer cells and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor-like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. IL12B/IL-12B is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine is important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. IL12B/IL-12B associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine that functions in innate and adaptive immunity. |
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