| Catalog No. | Size | Price (USD) |
| 101742-T04-50 | 50 µL | $147.96 |
| 101742-T04-100 | 100 µL | $251.64 |
| 101742-T04-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-MSL2L1/MSL2 Antibody, Rabbit Polyclonal |
| Validated applications | IP (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human MSL2L1/MSL2 |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Human MSL2 |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human MSL2, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-FLJ10546 Antibody; Anti-KIAA1585 Antibody; Anti-MSL-2 Antibody; Anti-MSL2L1 Antibody; Anti-RNF184 Antibody
Image / Experimental Information
| Image 1 Description | MSL2 was immunoprecipitated using: Lane A:0.5 mg Hela Whole Cell Lysate 4 µL anti-MSL2 rabbit polyclonal antibody and 15 μl of 50 % Protein G agarose. Primary antibody: Anti-MSL2 rabbit polyclonal antibody,at 1:100 dilution Secondary antibody: Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution Developed using the odssey technique. Performed under reducing conditions. Predicted band size: 44 kDa Observed band size: 44 kDa |
| Image 1 Alt Text | Human MSL2 / MSL2L1 Immunoprecipitation(IP) 15198 |
| Image 1 URL | Source image |
Background Information
| Description | MSL2 was associated with those genes responding to the virus. Mechanistically, MSL2 could maintain HBV cccDNA stability through degradation of APOBEC3B by ubiquitylation in hepatoma cells. MSL2 is an E3 ligase that ubiquitylates itself and the other associated components when their stoichiometry is unbalanced, uncovering proteasome-dependent degradation as an additional layer of homeostatic control of MSL levels. MSL2, together with MSL1, has robust histone ubiquitylation activity that mainly targets nucleosomal H2B on lysine 34 (H2B K34ub), a site within a conserved basic patch on H2B tail. |
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