Anti-IL-17A Antibody, Rabbit Polyclonal sinobiological 51065-T48
$243.00
In stock
SKU
51065-T48
| Catalog No. | Size | Price (USD) |
| 51065-T48-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-IL-17A Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse IL-17A |
| Immunogen | Recombinant Mouse IL17 Protein (Catalog#51065-MNAE) |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse IL17 (rM IL17; Catalog#51065-MNAE; Q62386; Thr22-Ala158). IL17 specific IgG was purified by Mouse IL17 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-Ctla-8 Antibody; Anti-Ctla8 Antibody; Anti-IL-17 Antibody; Anti-IL-17A Antibody; Anti-Il17 Antibody; Anti-Il17a Antibody
Image / Experimental Information
| Image 1 Description | Anti-IL17 rabbit polyclonal antibody at 1:500 dilution Lane A: Mouse slpeen tissue lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:17 kDa Observed band size:18 kDa |
| Image 1 Alt Text | Mouse IL17 Western blot (WB) 36885 |
| Image 1 URL | Source image |
Background Information
| Full Name | interleukin 17A |
| Description | IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis. |
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