| Catalog No. | Size | Price (USD) |
| 310365-T08-50 | 50 µL | $147.96 |
| 310365-T08-100 | 100 µL | $251.64 |
| 310365-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Caspase-9 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Caspase-9 |
| Immunogen | E. coli-derived Human CASP9 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human CASP9 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-APAF-3 Antibody; Anti-APAF3 Antibody; Anti-ICE-LAP6 Antibody; Anti-MCH6 Antibody; Anti-PPP1R56 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human Caspase-9 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human Caspase-9 Immunohistochemistry(IHC) 29859 |
| Image 1 URL | Source image |
Background Information
| Full Name | caspase 9, apoptosis-related cysteine peptidase |
| Description | Neural tube defects (NTDs) are birth defects of the nervous system and are the second most frequent cause of birth defects worldwide. The etiology of NTDs is complicated and involves both genetic and environmental factors. CASP9 is an initiator caspase in the intrinsic apoptosis pathway, which in Casp9-/- mice has been shown to result in NTDs because of decreased apoptosis. HSP90 inhibitors are identified here as a pharmacological approach for targeting autophagy via destabilization of ATG7, while an induced expression of CASP9, but not its apoptotic activity, is identified as a resistance mechanism to the cellular stress brought about by HSP90 inhibition. |
| Related Pathways |
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