| Catalog No. | Size | Price (USD) |
| 201463-T08-50 | 50 µL | $147.96 |
| 201463-T08-100 | 100 µL | $251.64 |
| 201463-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Kininogen 1 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Kininogen 1 |
| Immunogen | E. coli-derived Human Kininogen 1/KNG1 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human Kininogen 1/KNG1 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-BDK Antibody; Anti-BK Antibody; Anti-HAE6 Antibody; Anti-HK Antibody; Anti-HMWK Antibody; Anti-KNG Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human KNG1 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human Kininogen 1 Immunohistochemistry(IHC) 23902 |
| Image 1 URL | Source image |
Background Information
| Full Name | kininogen 1 |
| Description | Kininogen-1, also known as high molecular weight kininogen, Williams-Fitzgerald-Flaujeac factor, Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, KNG1, and BDK, is a secreted protein that contains three cystatin domains. Kininogen-1 / KNG1 is a protein from the blood coagulation system as well as the kinin-kallikrein system. It is a protein that adsorbs to the surface of biomaterials that come in contact with blood. Kininogen-1 / KNG1 circulates throughout the blood and quickly adsorbs to the material surfaces. Kininogen-1 / KNG1 is one of the early participants of the intrinsic pathway of coagulation, together with Factor XII (Hageman factor) and prekallikrein. Kininogen-1 / KNG1 is one of the kininogens, a class of proteins. As with many other coagulation proteins, the protein was initially named after the patients in whom deficiency was first observed. When the clinical data were combined, it turned out that all patients had a deficiency of the same protein. Defects in KNG1 are the cause of high molecular weight kininogen deficiency (HMWK deficiency) which is an autosomal recessive coagulation defect. Patients with HWMK deficiency do not have a hemorrhagic tendency, but they exhibit abnormal surface-mediated activation of fibrinolysis. |
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| References |
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