| Catalog No. | Size | Price (USD) |
| 207070-T08-50 | 50 µL | $147.96 |
| 207070-T08-100 | 100 µL | $251.64 |
| 207070-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Cytokeratin 10 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Cytokeratin 10 |
| Immunogen | E. coli-derived Human KRT10 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human KRT10 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-BCIE Antibody; Anti-BIE Antibody; Anti-CK10 Antibody; Anti-EHK Antibody; Anti-EHK2 Antibody; Anti-EHK2A Antibody; Anti-EHK2B Antibody; Anti-IHL Antibody; Anti-K10 Antibody; Anti-KPP Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human KRT10 in human skin with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human KRT10 Immunohistochemistry(IHC) 29857 |
| Image 1 URL | Source image |
Background Information
| Full Name | keratin 10 |
| Description | KRT10 was identified as a differently expressed protein in cisplatin-treated C13K/PTEN cells. Further study confirmed that cisplatin could induce upregulation of KRT10 mRNA and protein in C13K/PTEN cells and there was a direct interaction between KRT10 and PTEN. KRT10 is a downstream molecule of PTEN which improves cisplatin-resistance of ovarian cancer and forced KRT10 overexpression may also act as a therapeutic method for overcoming MDR in ovarian cancer. The substitution of arginine (R) to histidine (H) at amino acid residue 156 (R156H) of the coiled 1A region is one of the most frequent mutations of KRT10. Ichthyosis with confetti (IWC) is a genodermatosis caused by dominant-negative mutations in the gene encoding keratin 10 (KRT10). Recombinant adenovirus-mediated overexpression of KRT10 and PTEN may improve the cisplatin resistance of ovarian cancer in vitro and in vivo. |
| References |
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