| Catalog No. | Size | Price (USD) |
| 202120-T40-50 | 50 µL | $147.96 |
| 202120-T40-100 | 100 µL | $251.64 |
| 202120-T40-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-KRT6A/Cytokeratin6A Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human KRT6A/Cytokeratin6A |
| Immunogen | E. coli-derived Human KRT6A/Cytokeratin6A fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human KRT6A/Cytokeratin6A fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CK-6C Antibody; Anti-CK-6E Antibody; Anti-CK6A Antibody; Anti-CK6C Antibody; Anti-CK6D Antibody; Anti-K6A Antibody; Anti-K6C Antibody; Anti-K6D Antibody; Anti-KRT6C Antibody; Anti-KRT6D Antibody; Anti-PC3 Antibody
Image / Experimental Information
| Image 1 Description | Anti-KRT6A rabbit polyclonal antibody at 1:10000 dilution Lane A: A431 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:60 kDa Observed band size:60 kDa (We are unsure as to the identity of these extra bands.) |
| Image 1 Alt Text | Human KRT6A/Cytokeratin6A Western blot (WB) 23221 |
| Image 1 URL | Source image |
| Image 2 Description | Anti-KRT6A rabbit polyclonal antibody at 1:10000 dilution Lane A: A431 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:60 kDa Observed band size:60 kDa (We are unsure as to the identity of these extra bands.) |
| Image 2 Alt Text | Human KRT6A/Cytokeratin6A Immunohistochemistry(IHC) 23222 |
| Image 2 URL | Source image |
Background Information
| Full Name | keratin 6A, type II |
| Description | Mutations in the KRT6A or KRT16 gene cause pachyonychia congenita type 1 (PC-1), while mutations in KRT16 or KRT6C underlie focal palmoplantar keratoderma (FPPK). Pachyonychia congenita (PC) is an autosomal dominant, very rare keratin disorder caused by mutations in any of at least four genes (KRT6A, KRT6B, KRT16, or KRT17), which can lead to hypertrophic nail dystrophy and palmoplantar keratoderma, among other manifestations. A de novo missense mutation in the KRT6A gene, I462S, has been found in a sporadic PC-1 patient. The identification of this novel mutation in the KRT6A gene provides further evidence that mutation in the KRT6A gene causes PC-1 phenotype. |
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