| Catalog No. | Size | Price (USD) |
| 50446-R009-A-25 | 25 Tests | $103.68 |
| 50446-R009-A-100 | 100 Tests | $222.17 |
General Information
| Product name | Recombinant Anti-B7-1/CD80 Antibody (APC), Rabbit Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse B7-1/CD80 |
| Immunogen | Recombinant Mouse CD80/B7-1 Protein (Catalog#50446-M08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD80/B7-1 (rM CD80/B7-1; Catalog#50446-M08H; Q00609-1; Met1-Lys245) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Source | Monoclonal Rabbit IgG Clone #009 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Concentration | 5 μl/Test, 0.1 mg/ml |
| Conjugate | APC |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
Synonyms: Anti-B7 Antibody; Anti-B71 Antibody; Anti-Cd28l Antibody; Anti-Cd80 Antibody; Anti-Ly-53 Antibody; Anti-Ly53 Antibody; Anti-MIC17 Antibody; Anti-TSA1 Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of Mouse CD80 expression on LPS-stimulated BABL/c splenocytes. Cells were stained with APC-conjugated anti-Mouse CD80. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Image 1 Alt Text | Mouse CD80/B7-1 Flow Cytometry (FC) 18497 |
| Image 1 URL | Source image |
Background Information
| Full Name | CD80 molecule |
| Description | The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas. |
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| References |
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title: Low-Dose Ad26.COV2.S Protection Against SARS-CoV-2 Challenge in Rhesus Macaques
authors: He Xuan; Chandrashekar Abishek; ...; Barouch Dan H.
journal: bioRxiv
date: 2021-01-27
doi: 10.1101/2021.01.27.428380
cited_by_count: 0
techniques: Blocking Assay; Flow Cytometry; Incubation; Labeling; Staining
bioz_score: 90
