| Catalog No. | Size | Price (USD) |
| 103740-T08-50 | 50 µL | $147.96 |
| 103740-T08-100 | 100 µL | $251.64 |
| 103740-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Cdc25B Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse Human (Species predicted to react based on 100% sequence homology) |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Mouse Cdc25B |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Mouse Cdc25B, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-Cdc25b Antibody; Anti-Cdc25m2 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of mouse Cdc25b in mouse kidney with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Mouse Cdc25B Immunohistochemistry(IHC) 20060 |
| Image 1 URL | Source image |
Background Information
| Description | CDC25 phosphatases are key cell cycle regulators and represent very attractive but challenging targets for anticancer drug discovery. CDC25B may be used as a potential prognostic marker in the pathogenesis of retinoblastoma. In mitosis, Kiz is a new substrate of CDC25B whose dephosphorylation following CDC25B stabilization leads to the formation of multipolar spindles. Furthermore, endogenous Kiz and CDC25B interact only in mitosis, suggesting that Kiz phosphorylation depends on a balance between CDC25B and Plk1 activities. The abnormal expression of CDC25B phosphatases detected in a number of tumors implies that their dysregulation is involved in malignant transformation. Both CDC25B and PED/PEA-15 play a certain role in the carcinogenesis of esophageal cancer, they will be the new diagnostic/therapeutic targets in esophageal carcinoma. |
| Research Areas |
|
-HD12MY0361-200-mouse-kidney-IHC-P.png){kind=link}