| Catalog No. | Size | Price (USD) |
| 50718-R007-F-25 | 25 Tests | $103.68 |
| 50718-R007-F-100 | 100 Tests | $133.30 |
General Information
| Product name | Recombinant Anti-DPP-4/CD26/DPPIV Antibody (FITC), Rabbit Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse DPP-4/CD26/DPPIV |
| Immunogen | Recombinant Mouse DPP4 / CD26 Protein (Catalog#50718-M08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse DPP4 / CD26 (rM DPP4 / CD26; Catalog#50718-M08H; NP_034204.1; Ser29-His760) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| Source | Monoclonal Rabbit IgG Clone #007 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Concentration | 5 μl/Test, 0.1 mg/ml |
| Conjugate | FITC |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
Synonyms: Anti-Cd26 Antibody; Anti-Dpp-4 Antibody; Anti-Dpp4 Antibody; Anti-THAM Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of Mouse DPP4(CD26) expression on BABL/c splenocytes. Cells were stained with FITC-conjugated anti-Mouse DPP4(CD26). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Image 1 Alt Text | Mouse DPP4 / CD26 Flow Cytometry (FC) 17629 |
| Image 1 URL | Source image |
Background Information
| Full Name | dipeptidylpeptidase 4 |
| Description | Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the N-terminus of polypeptides, such as chemokines, neuropeptides, and peptide hormones. The enzyme is a type II transmembrane glycoprotein, expressed on the surface of many cell types. It is also present in serum and other body fluids in a truncated form (sCD26/DPPIV). The soluble CD26 (sCD26) as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas. As both a regulatory enzyme and a signalling factor, DPP4 has been evaluated and described in many studies. DPP4 inhibition results in increased blood concentration of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP). This causes an increase in glucose-dependent stimulation, resulting in a lowering of blood glucose levels. Recent studies have shown that DPP4 inhibitors can induce a significant reduction in glycosylated haemoglobin (HbA(1c)) levels, either as monotherapy or as a combination with other antidiabetic agents. Research has also demonstrated that DPP4 inhibitors portray a very low risk of hypoglycaemia development, and are a new pharmacological class of drugs for treating Type 2 diabetes. |
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