| Catalog No. | Size | Price (USD) |
| 50059-RP01-100 | 100 µL | $147.96 |
| 50059-RP01-200 | 200 µL | $251.64 |
| 50059-RP01-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-M-CSFR/CSF1R Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse M-CSFR/CSF1R |
| Immunogen | Recombinant Mouse CSF1R / MCSF Receptor / CD115 protein (Catalog#50059-M08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse CSF1R / MCSF Receptor / CD115 (rM CSF1R / MCSF Receptor / CD115; Catalog#50059-M08H; NP_001032948.2; Met 1-Ser 511). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CD115 Antibody; Anti-CSF-1R Antibody; Anti-Csf1r Antibody; Anti-Csfmr Antibody; Anti-Fim-2 Antibody; Anti-Fim2 Antibody; Anti-Fms Antibody; Anti-M-CSF-R Antibody; Anti-M-CSFR Antibody
Image / Experimental Information
| Image 1 Description | Anti-CSF1R rabbit polyclonal antibody at 1:500 dilution Lane A: RAW264.7 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti- Rabbit IgG H&L (Dylight 800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size:109 kDa Observed band size:155 kDa (We are unsure as to the identity of these extra bands.) |
| Image 1 Alt Text | Mouse MCSF Receptor/CSF1R/CD115 Western blot (WB) 17399 |
| Image 1 URL | Source image |
Background Information
| Full Name | colony stimulating factor 1 receptor |
| Description | M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein is consisted by an extracellular ligand-binding domain, a single membrane-spanning segment, and an intracellular tyrosine kinase domain. Binding of CSF1 activates the receptor kinase, leading to "autophosphorylation" of receptor subunits and the concomitant phosphorylation of a series of cellular proteins on tyrosine residues. CSF1R is a tyrosine kinase receptor that is absolutely required for macrophage differentiation and thus occupies a central role in hematopoiesis. CSF1 and its receptor (CSF1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. This apparent role for CSF1/CSF1R in normal mammary gland development is very intriguing because this receptor/ligand pair has also been found to be important in the biology of breast cancer in which abnormal expression of CSF1 and its receptor correlates with tumor cell invasiveness and adverse clinical prognosis. Tumor cell expression of CSF1R is under the control of several steroid hormones (glucocorticoids and progestins) and the binding of several bHLH transcription factors, while tumor cell expression of CSF-1 appears to be regulated by other hormones, some of which are involved in normal lactogenic differentiation. However, studies have demonstrated that CSF1 and CSF1R have additional roles in mammary gland development during pregnancy and lactation. The role of CSF1 and CSF1R in normal and neoplastic mammary development that may elucidate potential relationships of growth factor-induced biological changes in the breast during pregnancy and tumor progression. |
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| References |
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title: Soluble CSF1R promotes microglial activation and amyloid clearance in alzheimer’s disease
authors: Lianshuai Zhang; Kai Chen; ...; Xiao-Fen Chen
journal: Journal of neuroinflammation
date: 2025-10-28
doi: 10.1186/s12974-025-03558-5
cited_by_count: 0
techniques: Activation Assay; Activity Assay; Apoptosis Assay; Biomarker Discovery; CCK-8 Assay; Chemotaxis Assay; Control; Enzyme-linked Immunosorbent Assay; Expressing; Flow Cytometry; Generated; Immunofluorescence; Immunostaining; In Vitro; In Vivo; Incubation; Injection; Inverted Microscopy; Marker; Mass Spectrometry; Membrane; Migration; Protease Inhibitor; Purification; Quantitative Proteomics; Reverse Transcription Polymerase Chain Reaction; SDS Page; Silver Staining; Software; Staining; TUNEL Assay; Western Blot
bioz_score: 93
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