Anti-Ephrin-A1 Antibody, Rabbit Polyclonal sinobiological 50593-RP01

$143.00
In stock
SKU
50593-RP01
Catalog No.SizePrice (USD)
50593-RP01-100100 µL$147.96
50593-RP01-200200 µL$251.64
50593-RP01-400400 µL$355.32

General Information

Product nameAnti-Ephrin-A1 Antibody, Rabbit Polyclonal
Validated applicationsELISA (FAQ Protocol)
Species reactivityReacts with: Mouse
SpecificityMouse Ephrin-A1
ImmunogenRecombinant Mouse Ephrin-A1 / EFNA1 protein (Catalog#50593-M08H)
PreparationProduced in rabbits immunized with purified, recombinant Mouse Ephrin-A1 / EFNA1 (rM Ephrin-A1 / EFNA1; Catalog#50593-M08H;NP_034237.3; Met 1-Ser 182). Total IgG was purified by Protein A affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A
Formulation0.2 μm filtered solution in PBS
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-B61 Antibody; Anti-Efl1 Antibody; Anti-Efna1 Antibody; Anti-Epgl1 Antibody; Anti-Epl1 Antibody; Anti-Eplg1 Antibody; Anti-Lerk1 Antibody

Background Information

Full Nameephrin-A1
DescriptionEPH-related receptor tyrosine kinase ligand 1 (abbreviated as Ephrin-A1) also known as ligand of eph-related kinase 1 or EFNA1, is a member of the ephrin (EPH) family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin-A1/EFNA1 and its Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. An exception is the EphA4 receptor, which binds both subclasses of ephrins. Ephrin-A1 and one of its receptor EphA2 were expressed in xenograft endothelial cells and also tumor cells and play a role in human cancers, at least in part by influencing tumor neovascularization.
References
  1. Deroanne C, et al. (2003) EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway. J Cell Sci. 116(7): 1367-76.
  2. Ojima T, et al. (2006) EphrinA1 inhibits vascular endothelial growth factor-induced intracellular signaling and suppresses retinal neovascularization and blood-retinal barrier breakdown. Am J Pathol. 168(1): 331-9.
  3. Wu D, et al. (2004) Prognostic value of EphA2 and EphrinA-1 in squamous cell cervical carcinoma. Gynecol Oncol. 94(2): 312-9.

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