| Catalog No. | Size | Price (USD) |
| 51064-RP01-100 | 100 µL | $147.96 |
| 51064-RP01-200 | 200 µL | $251.64 |
| 51064-RP01-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-ERBB4/Her4 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse ERBB4/Her4 |
| Immunogen | Recombinant Mouse ErbB4 / HER4 protein (Catalog#51064-M08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse ErbB4 / HER4 (rM ErbB4 / HER4; Catalog#51064-M08H; Q99P91; Met1-Leu652). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-c-erbB-4 Antibody; Anti-Erbb4 Antibody; Anti-Her4 Antibody; Anti-Mer4 Antibody
Background Information
| Full Name | erb-b2 receptor tyrosine kinase 4 |
| Description | ERBB4 is a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. ERBB4 is expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. And lower levels in thymus, lung, salivary gland, and pancreas. It specifically binds to and is activated by neuregulins, NRG-2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. ERBB4 also can be activated by other factors and induces a variety of cellular responses including mitogenesis and differentiation. ERBB4 regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. It is required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. ERBB4 also play a role on the normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. It is required for mammary gland differentiation, induction of milk proteins and lactation. |
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| References |
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title: Increased expression of EHF via gene amplification contributes to the activation of HER family signaling and associates with poor survival in gastric cancer
authors: Jing Shi; Yiping Qu; ...; Peng Hou
journal: Cell death & disease
date: 2016-10-01
pmid: 27787520
doi: 10.1038/cddis.2016.346
pmcid: 5134001
cited_by_count: 38
techniques: Activity Assay; Binding Assay; Construct; Cotransfection; In Vitro; Incubation; Luciferase; Plasmid Preparation; Quantitative RT-PCR; Reporter Gene Assay; Sequencing; Transfection; Western Blot
bioz_score: 90
