| Catalog No. | Size | Price (USD) |
| 50071-T16-50 | 50 µL | $147.96 |
| 50071-T16-100 | 100 µL | $251.64 |
| 50071-T16-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-FGFR3 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse FGFR3 |
| Immunogen | Recombinant Mouse FGFR3 / CD333 protein (Catalog#50071-M08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse FGFR3 / CD333 (Catalog#50071-M08H; NP_032036.2; Met1-Tyr367). FGFR3 / CD333 specific IgG was purified by Mouse FGFR3 / CD333 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CD333 Antibody; Anti-Fgfr-3 Antibody; Anti-Fgfr3 Antibody; Anti-Flg-2 Antibody; Anti-FR3 Antibody; Anti-HBGFR Antibody; Anti-Mfr3 Antibody; Anti-sam3 Antibody
Background Information
| Full Name | fibroblast growth factor receptor 3 |
| Description | FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. FGFRs are transmembrane catalytic receptors that have intracellular tyrosine kinase activity. Mutations in FGFR genes are the cause of several human developmental disorders characterized by skeletal abnormalities such as achondroplasia, and upregulation of FGFR expression may lead to cell transformation and cancer. FGFR3, a full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR3 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR3 binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. CD333 is the receptor for acidic and basic fibroblast growth factors. |
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