| Catalog No. | Size | Price (USD) |
| 50469-RP01-50 | 50 µL | $147.96 |
| 50469-RP01-100 | 100 µL | $251.64 |
| 50469-RP01-200 | 200 µL | $236.83 |
| 50469-RP01-400 | 400 µL | $340.51 |
General Information
| Product name | Anti-Interferon alpha/beta receptor 1 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse Interferon alpha/beta receptor 1 |
| Immunogen | Recombinant Mouse IFNAR-1 protein (Catalog#50469-M08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse IFNAR-1 / CRF2-1 (rM IFNAR-1; Catalog#50469-M08H; NP_034638.2; Met 1-Thr 429). Total IgG was purified by Protein A affinity chromatography . |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-Ifar Antibody; Anti-Ifnar Antibody; Anti-Ifnar1 Antibody; Anti-Ifrc Antibody; Anti-Infar Antibody
Image / Experimental Information
| Image 1 Description | Anti-IFNAR1 rabbit polyclonal antibody at 1:500 dilution Lane A: K562 Membrane Lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size:64 kDa Observed band size:55 kDa |
| Image 1 Alt Text | Mouse IFNAR1 Western blot (WB) 13676 |
| Image 1 URL | Source image |
Background Information
| Full Name | interferon (alpha, beta and omega) receptor 1 |
| Description | Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant-negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors. |
| References |
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