Anti-IL-13 R alpha 1/IL13RA1 Antibody, Rabbit Polyclonal sinobiological 50088-T16

$128.00
In stock
SKU
50088-T16
Catalog No.SizePrice (USD)
50088-T16-5050 µL$133.15
50088-T16-100100 µL$251.64
50088-T16-200200 µL$340.51

General Information

Product nameAnti-IL-13 R alpha 1/IL13RA1 Antibody, Rabbit Polyclonal
Validated applicationsELISA (FAQ Protocol)
Species reactivityReacts with: Mouse
SpecificityMouse IL-13 R alpha 1/IL13RA1
ImmunogenRecombinant Mouse IL13RA1/IL-13RA1 Protein (Catalog#50088-M08H)
PreparationProduced in rabbits immunized with purified, recombinant Mouse IL13RA1/IL-13RA1 (rM IL13RA1/IL-13RA1; Catalog#50088-M08H; NP_598751.3; Met1-Thr340). IL13RA1/IL-13RA1 specific IgG was purified by Mouse IL13RA1/IL-13RA1 affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A & Antigen Affinity
Formulation0.2 μm filtered solution in PBS
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-CD213a1 Antibody; Anti-IL-13R-alpha-1 Antibody; Anti-IL-13r[a] Antibody; Anti-Il13r Antibody; Anti-Il13ra Antibody; Anti-Il13ra1 Antibody; Anti-NR4 Antibody

Background Information

Full Nameinterleukin 13 receptor, alpha 1
DescriptionInterleukin 13 receptor, alpha 1, also known as IL13RA1/IL-13RA1 and CD213A1 (cluster of differentiation 213A1), is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. IL13RA1/IL-13RA1 serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2 and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3, and STAT6 induced by IL13 and IL4. IL13RA1/IL-13RA1 binds with low affinity to interleukin-13 (IL13). This subunit together with IL4RA can form a functional receptor for IL13. IL13RA1/IL-13RA1 also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
Related Pathways
  • AKT Signaling Pathway
  • Jak-Stat Signaling Pathway
  • Autophagy Pathway
  • Common G-Chain signaling pathway
References
  1. Kawakami M, et al . (2002) Mutation and functional analysis of IL-13 receptors in human malignant glioma cells. Oncol Res. 12 (11-12): 459-67.
  2. Umeshita-Suyama R, et al . (2000) Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activation. Int Immunol. 12 (11): 1499-509.
  3. He JQ, et al . (2003) Polymorphisms in the IL13, IL13RA1, and IL4RA genes and rate of decline in lung function in smokers. Am J Respir. Cell Mol Biol. 28 (3): 379-85.

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