| Catalog No. | Size | Price (USD) |
| 50138-R110-50 | 50 µL | $177.58 |
| 50138-R110-100 | 100 µL | $340.51 |
General Information
| Product name | Recombinant Anti-IL-25/IL-17E Antibody, Rabbit Monoclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse IL-25/IL-17E |
| Immunogen | Recombinant Mouse IL-25 Protein (Catalog#50138-M07H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL-25 (rM IL-25; Catalog#50138-M07H; NP_542767.1; Val 17-Ala 169). |
| Source | Monoclonal Rabbit IgG Clone #110 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-IL-17e Antibody; Anti-IL-25 Antibody; Anti-Il17e Antibody; Anti-Il25 Antibody
Background Information
| Full Name | interleukin 25 |
| Description | Interleukin-25 (IL-25) is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. IL-25 is a member of the IL-17 family of cytokines. However, unlike the other members of this family, IL-25 promotes T helper (Th) 2 responses. IL-25 also regulates the development of autoimmune inflammation mediated by IL-17–producing T cells. IL-25 and IL-17, being members of the same cytokine family, play opposing roles in the pathogenesis of organ-specific autoimmunity. IL-25 promotes cell expansion and Th2 cytokine production when Th2 central memory cells are stimulated with thymic stromal lymphopoietin (TSLP)–activated dendritic cells (DCs), homeostatic cytokines, or T cell receptor for antigen triggering. Elevated expression of IL-25 and IL-25R transcripts was observed in asthmatic lung tissues and atopic dermatitis skin lesions, linking their possible roles with exacerbated allergic disorders. A plausible explanation that IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of adaptive Th2 memory cells had been provided. |
| Related Pathways |
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| References |
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title: Trained immunity of intestinal tuft cells during infancy enhances host defense against enteroviral infections in mice
authors: Deyan Chen; Jing Wu; ...; Zhiwei Wu
journal: EMBO Molecular Medicine
date: 2024-09-11
pmid: 39261649
pmcid: 11479266
cited_by_count: 9
techniques: Recombinant; Sequencing; Software
bioz_score: 92
