| Catalog No. | Size | Price (USD) |
| 50310-T52-50 | 50 µL | $147.96 |
| 50310-T52-100 | 100 µL | $251.64 |
| 50310-T52-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-kynureninase/KYNU Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol), IP (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse kynureninase/KYNU |
| Immunogen | Recombinant Mouse KYNU Protein (Catalog#50310-M08B) |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse KYNU (rM KYNU; Catalog#50310-M08B; Q9CXF0; Met1-Ser464). KYNU specific IgG was purified by Mouse KYNU affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-4432411A05Rik Antibody; Anti-Kynu Antibody
Image / Experimental Information
| Image 1 Description | Mouse KYNU was immunoprecipitated using: Lane A:0.5 mg A549 Whole Cell Lysate 2 µL anti-Mouse KYNU rabbit polyclonal antibody and 15 μl of 50 % Protein G agarose. Primary antibody: Anti-Mouse KYNU rabbit polyclonal antibody,at 1:200 dilution Secondary antibody: Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution Developed using the odssey technique. Performed under reducing conditions. Predicted band size: 52 kDa Observed band size: 52 kDa |
| Image 1 Alt Text | Mouse KYNU Immunoprecipitation(IP) 3521 |
| Image 1 URL | Source image |
| Image 2 Description | Mouse KYNU was immunoprecipitated using: Lane A:0.5 mg A549 Whole Cell Lysate 2 µL anti-Mouse KYNU rabbit polyclonal antibody and 15 μl of 50 % Protein G agarose. Primary antibody: Anti-Mouse KYNU rabbit polyclonal antibody,at 1:200 dilution Secondary antibody: Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution Developed using the odssey technique. Performed under reducing conditions. Predicted band size: 52 kDa Observed band size: 52 kDa |
| Image 2 Alt Text | Mouse KYNU Western blot (WB) 13662 |
| Image 2 URL | Source image |
Background Information
| Full Name | kynureninase |
| Description | KYNU (Kynureninase) is a Protein Coding gene. KYNU is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Genetic studies in the mouse and the human suggest that kynureninase activity may influence blood pressure and renal function. The gene coding kynureninase (KYNU) is also located on chromosome band 2q14-q23, where a linkage peak for essential hypertension was previously detected in the Chinese Han population. The results show that the rare KYNU variant Arg188Gln affects kynureninase activity and are consistent with the hypothesis that this mutation can predispose to essential hypertension. Diseases associated with KYNU include Hydroxykynureninuria and Vertebral, Cardiac, Renal, And Limb Defects Syndrome 2. |
| References |
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