Anti-CD27/TNFRSF7 Antibody, Rabbit Polyclonal sinobiological 10039-T56

$243.00
In stock
SKU
10039-T56
Catalog No.SizePrice (USD)
10039-T56-100100 µL$251.64

General Information

Product nameAnti-CD27/TNFRSF7 Antibody, Rabbit Polyclonal
Validated applicationsWB (FAQ Protocol), ELISA (FAQ Protocol), IHC-P (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman CD27/TNFRSF7
ImmunogenRecombinant Human CD27/TNFRSF7 Protein (Catalog#10039-H31H)
PreparationProduced in rabbits immunized with purified, recombinant Human CD27/TNFRSF7 (rh CD27/TNFRSF7; Catalog#10039-H31H; P26842; Met1-Ile192). CD27/TNFRSF7 specific IgG was purified by Human CD27/TNFRSF7 affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A & Antigen Affinity
Formulation0.2 μm filtered solution in PBS
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-S152 Antibody; Anti-S152. LPFS2 Antibody; Anti-T14 Antibody; Anti-TNFRSF7 Antibody; Anti-Tp55 Antibody

Image / Experimental Information

Image 1 DescriptionAnti-CD27 rabbit polyclonal antibody at 1:1000 dilution Lane A: Raji Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:29 kDa
Image 1 Alt TextHuman CD27/TNFRSF7 Western blot (WB) 39617
Image 1 URLSource image
Image 2 DescriptionAnti-CD27 rabbit polyclonal antibody at 1:1000 dilution Lane A: Raji Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:29 kDa
Image 2 Alt TextHuman CD27/TNFRSF7 Immunohistochemistry(IHC) 39618
Image 2 URLSource image
Image 3 DescriptionAnti-CD27 rabbit polyclonal antibody at 1:1000 dilution Lane A: Raji Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:29 kDa
Image 3 Alt TextHuman CD27/TNFRSF7 Immunohistochemistry(IHC) 39619
Image 3 URLSource image

Background Information

Full NameCD27 molecule
DescriptionCD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has an important role in the generation of T cell immunity and is an robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.
Research Areas
  • Cancer Drug Targets
Tags
  • Cancer Immunotherapy
  • Co-stimulatory Immune Checkpoint Targets
  • Immune Checkpoint
  • Immune Checkpoint Detection: Antibodies
  • Immune Checkpoint Detection: ELISA Antibodies
  • Immune Checkpoint Detection: FCM Antibodies
  • Immune Checkpoint Detection: ICC Antibodies
  • Immune Checkpoint Detection: IHC Antibodies
  • Immune Checkpoint Proteins
  • Immune Checkpoint Targets
  • Immunotherapy
  • Targeted Therapy
References
  1. Drner T, et al. (2004) Correlation of circulating CD27 high plasma cells and disease activity in systemic lupus erythematosus. Lupus. 13(5): 283-9.
  2. Sahota SS, et al. (2009) CD27 in defining memory B-cell origins in Waldenstrm's macroglobulinemia. Clin Lymphoma Myeloma. 9(1): 33-5.
  3. Jiang J, et al. (2010) Reduced CD27 expression on antigen-specific CD4+ T cells correlates with persistent active tuberculosis. J Clin Immunol. 30(4): 566-73.

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