| Catalog No. | Size | Price (USD) |
| 50192-R311-50 | 50 µL | $177.58 |
| 50192-R311-100 | 100 µL | $340.51 |
General Information
| Product name | Recombinant Anti-VE-Cadherin Antibody, Rabbit Monoclonal |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse VE-Cadherin |
| Immunogen | Recombinant Mouse VE-Cadherin / CD144 / CDH5 Protein (Catalog#50192-M08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse VE-Cadherin / CD144 / CDH5 (rM VE-Cadherin / CD144 / CDH5; Catalog#50192-M08H; NP_033998.2; Met1-Ala592). |
| Source | Monoclonal Rabbit IgG Clone #311 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-7B4 Antibody; Anti-Cd144 Antibody; Anti-Cdh5 Antibody; Anti-VE-Cad Antibody; Anti-Vec Antibody; Anti-VEcad Antibody; Anti-VECD Antibody
Image / Experimental Information
| Image 1 Description | Anti-CDH5 rabbit monoclonal antibody at 1:500 Lane A: Rat lung tissue lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size:88 kDa Observed band size:88 kDa |
| Image 1 Alt Text | Mouse VE-Cadherin/CD144 Western blot (WB) 7026 |
| Image 1 URL | Source image |
Background Information
| Full Name | cadherin 5, type 2 (vascular endothelium) |
| Description | Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis. |
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