| Catalog No. | Size | Price (USD) |
| 203501-T36-50 | 50 µL | $147.96 |
| 203501-T36-100 | 100 µL | $251.64 |
| 203501-T36-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-MRE11 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), IP (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human MRE11 |
| Immunogen | E. coli-derived Human MRE11 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human MRE11 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ATLD Antibody; Anti-HNGS1 Antibody; Anti-MRE11A Antibody; Anti-MRE11B Antibody
Image / Experimental Information
| Image 1 Description | Anti-MRE11 rabbit polyclonal antibody at 1:500 dilution Lane A: HeLa Whole Cell Lysate Lane B: Jurkat Whole Cell Lysate Lane C: A431 Whole Cell Lysate Lane D: K562 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:81 kDa Observed band size:81 kDa (We are unsure as to the identity of these extra bands.) |
| Image 1 Alt Text | Human MRE11 Western blot (WB) 32766 |
| Image 1 URL | Source image |
| Image 2 Description | Anti-MRE11 rabbit polyclonal antibody at 1:500 dilution Lane A: HeLa Whole Cell Lysate Lane B: Jurkat Whole Cell Lysate Lane C: A431 Whole Cell Lysate Lane D: K562 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:81 kDa Observed band size:81 kDa (We are unsure as to the identity of these extra bands.) |
| Image 2 Alt Text | Human MRE11 Immunoprecipitation(IP) 32767 |
| Image 2 URL | Source image |
Background Information
| Description | MRE11 and NBS1 function together as components of a MRE11/RAD5/NBS1 protein complex. The MRN complex consisting of MRE11A-RAD5-NBS1 proteins is involved in the repair of double-strand breaks, and mutations in genes coding for the MRN complex have been identified in families with breast and ovarian cancer. In human-synovium chimeric mice, MRE11A(low) T cells were tissue-invasive and pro-arthritogenic, and MRE11A reconstitution mitigated synovitis.MRE11A is a therapeutic target to combat immune aging and suppress dysregulated tissue inflammation. |
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