Anti-Adenylate Kinase 1 Antibody, Rabbit Polyclonal sinobiological 80583-T52

$143.00
In stock
SKU
80583-T52
Catalog No.SizePrice (USD)
80583-T52-5050 µL$147.96
80583-T52-100100 µL$251.64
80583-T52-200200 µL$355.32

General Information

Product nameAnti-Adenylate Kinase 1 Antibody, Rabbit Polyclonal
Validated applicationsWB (FAQ Protocol), ELISA (FAQ Protocol), IP (FAQ Protocol)
Species reactivityReacts with: Rat
SpecificityRat Adenylate Kinase 1
ImmunogenRecombinant Rat AK1 / Adenylate kinase 1 Protein (Catalog#80583-R07E)
PreparationProduced in rabbits immunized with purified, recombinant Rat AK1 / Adenylate kinase 1 (rR AK1 / Adenylate kinase 1; Catalog#80583-R07E; NP_077325.2; Met1-Lys194). AK1 / Adenylate kinase 1 specific IgG was purified by Rat AK1 / Adenylate kinase 1 affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A & Antigen Affinity
Formulation0.2 μm filtered solution in PBS
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-Ak 1 Antibody; Anti-Ak1 Antibody

Image / Experimental Information

Image 1 DescriptionAnti-AK1 rabbit polyclonal antibody at 1:500 dilution Lane A: Rat Heart tissue lysate Lane B: Rat Brain tissue lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:22 kDa Observed band size:22 kDa
Image 1 Alt TextRat Adenylate Kinase 1 Western blot (WB) 20226
Image 1 URLSource image
Image 2 DescriptionAnti-AK1 rabbit polyclonal antibody at 1:500 dilution Lane A: Rat Heart tissue lysate Lane B: Rat Brain tissue lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:22 kDa Observed band size:22 kDa
Image 2 Alt TextRat Adenylate Kinase 1 Immunoprecipitation(IP) 20227
Image 2 URLSource image

Background Information

Full Nameadenylate kinase 1
DescriptionThe adenylate kinase (AK) isoforms network plays an important role in the intracellular energy transfer processes, the maintenance of energy homeostasis, and it is a major player in AMP metabolic signaling circuits in some highly-differentiated cells. Three other biomarkers (AK1, CLIC1, and SOD1) were significantly increased in both adenoma and early colorectal cancer patient plasma samples and in plasma from colorectal cancer mouse models at preclinical stages compared with controls.Which can contribute to the detection of early-stage colorectal cancer and adenomas.
References
  1. Lu Q, et al. (1996) Adenylate kinase complements nucleoside diphosphate kinase deficiency in nucleotide metabolism. Proc Natl Acad Sci. 93 (12): 5720-5.
  2. Dzeja P, et al. (2009) Adenylate kinase and AMP signaling networks: Metabolic monitoring, signal communication and body energy sensing. Int J Mol Sci. 10 (4): 1729-72.
  3. Lagresle-Peyrou C, et al. (2008) Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nature Genetics. 41: 106 - 11.

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