| Catalog No. | Size | Price (USD) |
| 80299-R001-50 | 50 µL | $177.58 |
| 80299-R001-100 | 100 µL | $340.51 |
General Information
| Product name | Recombinant Anti-CD59 Antibody, Rabbit Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Rat |
| Specificity | Rat CD59 |
| Immunogen | Recombinant Rat CD59 Protein (Catalog#80299-R08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Rat CD59 (rR CD59; Catalog#80299-R08H; P27274; Met1-Asn100). |
| Source | Monoclonal Rabbit IgG Clone #001 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-Cd59 Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of Rat CD59 expression on SD rat bone marrow cells. Cells were stained with purified anti-Rat CD59, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Image 1 Alt Text | Rat CD59 Flow Cytometry (FC) 4896 |
| Image 1 URL | Source image |
Background Information
| Full Name | CD59 molecule |
| Description | CD59 glycoprotein, also known as 2 kDa homologous restriction factor, HRF2, MAC-inhibitory protein, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MIC11, MIRL and CD59, is a cell membrane protein which contains one UPAR/Ly6 domain. CD59 is a small, highly glycosylated, GPI-linked protein, with a wide expression profile. The soluble form of CD59 from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D). |
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