Recombinant Rat CLEC5A / MDL1 / MDL-1 protein (Catalog#80259-R07H)
Preparation
Produced in rabbits immunized with purified, recombinant Rat CLEC5A / MDL1 / MDL-1 (Catalog#80259-R07H; F7GAV1; Val30-Lys190). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Background Information
Full Name
C-type lectin domain family 5, member A
Description
CLEC5A, also known as MDL1 and MDL-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. CLEC5A with dnax-activation protein 12 and may play a role in cell activation. It also functions as a positive regulator of osteoclastogenesis. CLEC5A acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation .The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.
Research Areas
ITIM/ITAM Immunoreceptors and Related Molecules
References
Chen ST. et al., 2008, Nature. 453 (7195): 672-6.
Davila S. et al., 2010, Genes Immun. 11 (3): 232-8.
Hillier LW. et al., 2003, Nature. 424 (6945): 157-64.
