| Catalog No. | Size | Price (USD) |
| 50339-RP01-100 | 100 µL | $147.96 |
| 50339-RP01-200 | 200 µL | $251.64 |
| 50339-RP01-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-KIRREL3 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse KIRREL3 |
| Immunogen | Recombinant Mouse KIRREL3 / NEPH2 protein (Catalog#50339-M08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse KIRREL3 / NEPH2 (Catalog#50339-M08H; Q8BR86-1; Met1-Ala535). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-1500010O20Rik Antibody; Anti-2900036G11Rik Antibody; Anti-Kiaa1867 Antibody; Anti-Kirrel3 Antibody; Anti-mKIAA1867 Antibody; Anti-NEPH2 Antibody; Anti-SST4 Antibody
Background Information
| Full Name | kin of IRRE like 3 (Drosophila) |
| Description | Kin of IRRE-like protein 3 (KIRREL3) also known as nin of irregular chiasm-like protein 3 or nephrin-like protein 2 (NEPH2) is a member of the nephrin-like protein family of transmembrane proteins, which includes NEPH1 (KIRREL) and NEPH3 (KIRREL2). KIRREL3/NEPH2 is expressed in the fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of KIRREL3/NEPH2 interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. Mutations in KIRREL3/NEPH2 are associated with mental retardation autosomal dominant type 4. KIRREL3/NEPH2 expression is turned on in migrating Nucleogenesis of the pontine nucleus (PN) neurons only after they enter the presumptive nuclear region. KIRREL3/NEPH2 knockdown disrupted the nuclear organization of PN presumably by changing the migratory behavior of PN neurons inside the nuclear region. Moreover, overexpression of the cytoplasmic region of KIRREL3, which can sequester intracellular signaling of endogenous KIRREL3, resulted in similar phenotypes. Overall, these results suggest KIRREL3 is involved in the Nucleogenesis of the PN through the control of neuronal migration inside the nucleus. |
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