| Catalog No. | Size | Price (USD) |
| 80198-R002-50 | 50 µL | $177.58 |
| 80198-R002-100 | 100 µL | $340.51 |
General Information
| Product name | Recombinant Anti-IL-4R Antibody, Rabbit Monoclonal |
| Validated applications | ELISA (FAQ Protocol), FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Rat |
| Specificity | Rat IL-4R |
| Immunogen | Recombinant Rat IL-4R/CD124 Protein (Catalog#80198-R08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Rat IL-4R/CD124 (rR IL-4R/CD124; Catalog#80198-R08H; Q63257-1; Met1-Arg232). |
| Source | Monoclonal Rabbit IgG Clone #002 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-Il4r Antibody; Anti-Il4ra Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of rat IL4R(CD124) expression on SD rat splenocytes. Cells were stained with purified anti-rat IL4R(CD124), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Image 1 Alt Text | Rat IL4R Flow Cytometry (FC) 24100 |
| Image 1 URL | Source image |
Background Information
| Full Name | interleukin 4 receptor |
| Description | The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alters the behavior of the cell. Some CD proteins do not take part in the cell signal process but have other functions such as cell adhesion. CD124, also known as the interleukin 4 receptor (IL4R), is a typeⅠ transmembrane protein that can regulate IgE antibody production in B cells through binding to interleukin 4 and interleukin 13 and promote differentiation of Th2 cells through binding to interleukin 4. The membrane-bound form of CD124 can be hydrolyzed to a soluble form which can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. |
| Related Pathways |
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| References |
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