Human DICR/CLEC4A ELISA Kit sinobiological KIT11476
$714.00
In stock
SKU
KIT11476
| Catalog No. | Size | Price (USD) |
| KIT11476-1 | 1 Kit (96 Tests) | $740.55 |
General Information
| Product name | Human DICR/CLEC4A ELISA Kit |
| Specificity | This assay recognizes both recombinant and natural Human CLEC4A. |
| Conjugate | HRP |
| Shipping | This ELISA Kit is shipped at ambient temperature. |
| Storage | Unopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA |
| Assay type | Solid Phase Sandwich ELISA (quantitative) |
| Sample type | Lysate |
| Sensitivity | 13.18 pg/mL |
| Assay range | 78.125-5000 pg/mL |
| Materials provided | 1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Color Reagent A 7. Color Reagent B 8. Stop Solution |
| Product overview | This Human DICR/CLEC4A ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Human DICR/CLEC4A protein in Lysate . It contains recombinant Human DICR/CLEC4A, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use. |
Synonyms: CD367 ELISA Kit, Human; CLECSF6 ELISA Kit, Human; DCIR ELISA Kit, Human; DDB27 ELISA Kit, Human; HDCGC13P ELISA Kit, Human; hDCIR ELISA Kit, Human; LLIR ELISA Kit, Human
Image / Experimental Information
| Image 1 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 1 Alt Text | Human DCIR/CLEC4A/CLECSF6 ELISA Kit Standard Curve 104 |
| Image 1 URL | Source image |
Background Information
| Full Name | C-type lectin domain family 4 member A |
| Description | Dendritic cell immunoreceptor (DCIR), also known as C-type lectin domain family 4 member A (CLEC4A), C-type lectin superfamily member 6 (CLECSF6), is a single-pass type II C-type lectin receptor expressed mainly in dendritic cells (DCs), which is a negative regulator of DC expansion and has a crucial role in maintaining the homeostasis of the immune system. The Dectin-2 family of C-type lectins that includes Dectin-2, BDCA-2, DCIR, DCAR, Clecsf8 and Mincle. These type II receptors contain a single extracellular carbohydrate recognition domain and have diverse functions in both immunity and homeostasis. DCIR is the only member of the family which contains a cytoplasmic signalling motif and has been shown to act as an inhibitory receptor, while BDCA-2, Dectin-2, DCAR and Mincle all associate with FcRgamma chain to induce cellular activation, including phagocytosis and cytokine production. Dectin-2 and Mincle have been shown to act as pattern recognition receptors for fungi, while DCIR acts as an attachment factor for HIV. In addition to pathogen recognition, DCIR has been shown to be pivotal in preventing autoimmune disease by controlling dendritic cell proliferation. DCIR expressed on antigen presenting cells and granulocytes and acts as an inhibitory receptor via an intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM). It may also be involved via its ITIM motif in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. Additionally, DCIR can participate in the capture of HIV-1 and promote infection in trans and in cis of autologous CD4(+) T cells from human immature monocyte-derived DCs. DCIR acts as a ligand for HIV-1 and is involved in events leading to productive virus infection. |
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