Human COMP ELISA Kit sinobiological KIT10173

$400.00
In stock
SKU
KIT10173
Catalog No.SizePrice (USD)
KIT10173-11 Kit (96 Tests)$414.71

General Information

Product nameHuman COMP ELISA Kit
SpecificityThis assay recognizes both recombinant and natural Human COMP.
ConjugateHRP
ShippingThis ELISA Kit is shipped at ambient temperature.
StorageUnopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA
Assay typeSolid Phase Sandwich ELISA (quantitative)
Sample typeSerum
Sensitivity31.15 pg/mL
Assay range125-8000 pg/mL
Materials provided1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Color Reagent A 7. Color Reagent B 8. Stop Solution
Product overviewThis Human COMP ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Human COMP protein in Serum . It contains recombinant Human COMP, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use.

Synonyms: CTS2 ELISA Kit, Human; EDM1 ELISA Kit, Human; EPD1 ELISA Kit, Human; MED ELISA Kit, Human; PSACH ELISA Kit, Human; THBS5 ELISA Kit, Human; TSP-5 ELISA Kit, Human; TSP5 ELISA Kit, Human

Image / Experimental Information

Image 1 DescriptionThis standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
Image 1 Alt TextHuman COMP ELISA Kit Standard Curve 44
Image 1 URLSource image
Image 2 DescriptionThis standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
Image 2 Alt TextHuman COMP ELISA Kit Specificity 239
Image 2 URLSource image

Background Information

Full Namecartilage oligomeric matrix protein
DescriptionCartilage Oligomeric Matrix Protein (COMP), also referred to as Thrombospondin-5, is a non-collagenous extracellular matrix (ECM) protein and belongs to the subgroup B of the thrombospondin protein family. This protein is expressed primarily in cartilage, ligament, and tendon, and binds to other ECM proteins such as collagen I, II and IX with high affinities depending on the divalent cations Zn2+ or Ni2+. COMP is a secreted glycoprotein that is important for growth plate organization and function. It is suggested to play a role in cell growth and development, and recent studies have revealed the possible mechanism that it protects cells against death by elevating members of the IAP (inhibitor of apoptosis protein) family of survival proteins. Mutations in COMP cause two skeletal dysplasias, pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (EDM1), and up-regulated expression of COMP are observed in rheumatoid arthritis and certain carcinomas.
References
  1. Posey KL, et al. (2004) Role of TSP-5/COMP in pseudoachondroplasia. Int J Biochem Cell Biol. 36(6): 1005-12.
  2. Chen FH, et al. (2005) Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan. J Biol Chem. 282(34): 24591-8.
  3. Posey KL, et al. (2008) The role of cartilage oligomeric matrix protein (COMP) in skeletal disease. Curr Drug Targets. 9(10): 869-77.
  4. Tan K, et al. (2009) The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding. FASEB J. 23(8): 2490-501.

Reviews

Write Your Own Review
You're reviewing:Human COMP ELISA Kit sinobiological KIT10173
Your Rating
Copyright © 2025 Biogege, Inc. All rights reserved.