Mouse gp130/IL6ST ELISA Kit sinobiological KIT50135

$714.00
In stock
SKU
KIT50135
Catalog No.SizePrice (USD)
KIT50135-11 KIT (96 Tests)$740.55

General Information

Product nameMouse gp130/IL6ST ELISA Kit
SpecificityThis assay recognizes both recombinant and natural Mouse IL6ST.
ConjugateHRP
ShippingThis ELISA Kit is shipped at ambient temperature.
StorageUnopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA
Assay typeSolid Phase Sandwich ELISA (quantitative)
Sample typeSerum
Sensitivity9.44 pg/mL
Assay range23.44-1500 pg/mL
Materials provided1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Color Reagent A 7. Color Reagent B 8. Stop Solution
Product overviewThis Mouse gp130/IL6ST ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Mouse gp130/IL6ST protein in Serum . It contains recombinant Mouse gp130/IL6ST, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use.
InterferencePreparations of the following factors at 15 ng/mL in a mid-range recombinant Mouse IL6ST control were assayed for interference. No significant interference was observed.

Synonyms: 5133400A03Rik ELISA Kit, Mouse; CD130 ELISA Kit, Mouse; D13Ertd699e ELISA Kit, Mouse; gp130 ELISA Kit, Mouse; Il6st ELISA Kit, Mouse

Image / Experimental Information

Image 1 DescriptionThis standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
Image 1 Alt TextMouse IL6ST/gp130/CD130 ELISA Kit Standard Curve 23
Image 1 URLSource image
Image 2 DescriptionThis standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
Image 2 Alt TextMouse IL6ST/gp130/CD130 ELISA Kit Specificity 176
Image 2 URLSource image

Background Information

Full Nameinterleukin 6 signal transducer
DescriptionGlycoprotein 130 (also known as gp130, IL6ST, IL6-beta, or CD130) is a transmembrane protein that is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively, spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1, and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.
Related Pathways
  • AKT Signaling Pathway
  • Jak-Stat Signaling Pathway
  • Autophagy Pathway
  • IL12 signaling pathway
References
  1. Hibi, et al . (1990) Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell. 63 (6): 1149-57.
  2. Kim H, et al . (1997) Transmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cells. J Biol Chem. 272 (49): 30741-7.
  3. Giordano V, et al . (1997) Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase. J Immunol. 158 (9): 4097-103.

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