Human HRG/HPRG ELISA Kit sinobiological KIT10836
$714.00
In stock
SKU
KIT10836
| Catalog No. | Size | Price (USD) |
| KIT10836-1 | 1 Kit (96 Tests) | $740.55 |
General Information
| Product name | Human HRG/HPRG ELISA Kit |
| Specificity | This assay recognizes both recombinant and natural Human HPRG. |
| Conjugate | HRP |
| Shipping | This ELISA Kit is shipped at ambient temperature. |
| Storage | Unopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA |
| Assay type | Solid Phase Sandwich ELISA (quantitative) |
| Sample type | Serum |
| Sensitivity | 13.10 pg/mL |
| Assay range | 31.25-2000 pg/mL |
| Materials provided | 1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Standard Dilution Buffer 7. Color Reagent A 8. Color Reagent B 9. Stop Solution |
| Product overview | This Human HRG/HPRG ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Human HRG/HPRG protein in Serum . It contains recombinant Human HRG/HPRG, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use. |
Synonyms: HPRG ELISA Kit, Human; HRGP ELISA Kit, Human; THPH11 ELISA Kit, Human
Image / Experimental Information
| Image 1 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 1 Alt Text | Human HPRG/HRG ELISA Kit Standard Curve 81 |
| Image 1 URL | Source image |
Background Information
| Full Name | histidine-rich glycoprotein |
| Description | Histidine-rich glycoprotein, also known as HRG and HPRG, is a glycoprotein located in plasma and platelets and contains an unusually large amount of histidine and proline. In humans, five distinct domains are recognized in the mature HPRG molecule. There are two N-terminal cystatin-like modules (aa 19 - 254) and one His-Pro-rich region (aa 350 - 497) that is flanked by two Pro-rich segments (aa 276 - 321 and 498 - 525). The His-Pro-rich region contains 10 tandem repeats with an HHPHG motif, and the N- and C-termini are linked by a disulfide bond. The specific functions of HRG remain unclear, but it is known that the protein binds heme, dyes, and divalent metal ions. It inhibits rosette formation and interacts with heparin, thrombospondin, and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis, and the reduction of inhibition of coagulation indicate a potential prothrombotic effect. HPRG is evolutionarily, functionally, and structurally related to cleaved high molecular weight kininogen (HKa), an anti-angiogenic polypeptide that stimulates apoptosis of proliferating endothelial cells through binding to cell-surface tropomyosin. The antiangiogenic activity of the multidomain plasma protein HPRG is localized to its histidine-proline-rich (H/P) domain and has recently been shown to be mediated, at least partially, through binding to cell-surface tropomyosin in fibroblast growth factor-2-activated endothelial cells. |
| References |
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