Human IGFBP-3 ELISA Kit sinobiological KIT10430
$400.00
In stock
SKU
KIT10430
| Catalog No. | Size | Price (USD) |
| KIT10430-1 | 1 Kit (96 Tests) | $414.71 |
General Information
| Product name | Human IGFBP-3 ELISA Kit |
| Specificity | This assay recognizes both recombinant and natural Human IGFBP3. |
| Conjugate | HRP |
| Shipping | This ELISA Kit is shipped at ambient temperature. |
| Storage | Unopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA |
| Assay type | Solid Phase Sandwich ELISA (quantitative) |
| Sample type | Serum |
| Sensitivity | 1.37 pg/mL |
| Assay range | 19.53-1250 pg/mL |
| Materials provided | 1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Color Reagent A 7. Color Reagent B 8. Stop Solution |
| Product overview | This Human IGFBP-3 ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Human IGFBP-3 protein in Serum . It contains recombinant Human IGFBP-3, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use. |
Synonyms: BP-53 ELISA Kit, Human; IBP-3 ELISA Kit, Human; IBP3 ELISA Kit, Human; IGFBP-3 ELISA Kit, Human
Image / Experimental Information
| Image 1 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 1 Alt Text | Human IGFBP3/IGFBP-3 ELISA Kit Standard Curve 65 |
| Image 1 URL | Source image |
| Image 2 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 2 Alt Text | Human IGFBP3/IGFBP-3 ELISA Kit Specificity 219 |
| Image 2 URL | Source image |
Background Information
| Full Name | insulin-like growth factor binding protein 3 |
| Description | The Insulin-like Growth Factor (IGF) signaling system plays a central role in cellular growth, differentiation, and proliferation. IGFBP3 is the most abundant IGF binding protein in human serum and is a growth inhibitory, apoptosis-inducing molecule, capable of acting via IGF-dependent and IGF-independent mechanisms. It appears to function both by cell cycle blockade and the induction of apoptosis. IGFBP3 can be transported to the nucleus by an importin beta mediated mechanism, where it has been shown to interact with the retinoid X receptor alpha and possibly other nuclear elements. IGFBP3 antiproliferative signaling appears to require an active transforming growth factor-beta (TGF-beta) signaling pathway, and IGFBP3 stimulates phosphorylation of the TGF-beta signaling intermediates Smad2 and Smad3. IGFBP3 has IGF-independent roles in inhibiting cell proliferation in cancer cell lines. Nuclear transcription factor, retinoid X receptor (RXR)-alpha, and IGFBP3 functionally interact to reduce prostate tumor growth and prostate-specific antigen in vivo. Several clinical studies have proposed that individuals with IGFBP3 levels in the upper range of normal may have a decreased risk for certain common cancers. This includes evidence of a protective effect against breast cancer, prostate cancer, colorectal cancer, and lung cancer. Moreover, IGFBP3 inhibits insulin-stimulated glucose uptake into adipocytes independent of IGF. |
| References |
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