General Information
| Product name | Human IL-15 ELISA Kit |
| Specificity | This assay recognizes recombinant Human IL-15. |
| Conjugate | HRP |
| Shipping | This ELISA Kit is shipped at ambient temperature. |
| Storage | Unopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA |
| Assay type | Solid Phase Sandwich ELISA (quantitative) |
| Sample type | Recombinant protein |
| Sensitivity | 1.45 pg/mL |
| Assay range | 12.5-800 pg/mL |
| Materials provided | 1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Color Reagent A 7. Color Reagent B 8. Stop Solution |
| Product overview | This Human IL-15 ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Human IL-15 protein in Recombinant protein . It contains recombinant Human IL-15, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use. |
Synonyms: IL-15 ELISA Kit, Human; MGC9721 ELISA Kit, Human
Image / Experimental Information
| Image 1 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 1 Alt Text | Human IL-15 ELISA Kit Standard Curve 37293 |
| Image 1 URL | Source image |
Background Information
| Full Name | interleukin 15 |
| Description | The protein encoded by the IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietic receptor subunits and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively, spliced transcript variants of this gene have been reported. |
| Related Pathways | - AKT Signaling Pathway
- Jak-Stat Signaling Pathway
- Autophagy Pathway
- Common G-Chain signaling pathway
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| Tags | - Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
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| References | - Mongini PKA, Gupta R, Boyle E, et al. TLR-9 and IL-15 synergy promotes the in vitro clonal expansion of chronic lymphocytic leukemia B cells. Journal of immunology (Baltimore, Md : 1950). 2015;195(3):901-923.
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