Rat LIFR ELISA Kit sinobiological KIT80322
$714.00
In stock
SKU
KIT80322
| Catalog No. | Size | Price (USD) |
| KIT80322-1 | 1 Kit (96 Tests) | $740.55 |
General Information
| Product name | Rat LIFR ELISA Kit |
| Specificity | This assay recognizes both recombinant and natural Rat LIFR. |
| Conjugate | HRP |
| Shipping | This ELISA Kit is shipped at ambient temperature. |
| Storage | Unopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA |
| Assay type | Solid Phase Sandwich ELISA (quantitative) |
| Sample type | Serum |
| Sensitivity | 13 pg/mL |
| Assay range | 46.88-3000 pg/mL |
| Materials provided | 1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Color Reagent A 7. Color Reagent B 8. Stop Solution |
| Product overview | This Rat LIFR ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Rat LIFR protein in Serum . It contains recombinant Rat LIFR, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use. |
| Interference | Preparations of human LIFR ,LTF and mouse LIFR ,LTF at 50 ng/mL in a mid-range recombinant rat LIFR control were assayed for interference. No significant interference was observed. |
Synonyms: Lifr ELISA Kit, Rat
Image / Experimental Information
| Image 1 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 1 Alt Text | Rat LIFR/CD118 ELISA Kit Standard Curve 15929 |
| Image 1 URL | Source image |
| Image 2 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 2 Alt Text | Rat LIFR/CD118 ELISA Kit Specificity 15938 |
| Image 2 URL | Source image |
Background Information
| Full Name | leukemia inhibitory factor receptor alpha |
| Description | LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus affects the differentiation, proliferation, and survival of a wide variety of cells in the adult and the embryo. Besides LIF, LIFR can also bind to and activate CNTF (ciliary neurotrophic factor) and CLC (Cardiotrophin Like Cytokine). Evidence showed that in the retina, LIFR activating LIF, CT-1, and Cardiotrophin Like Cytokine (CLC) are strongly upregulated in response to preconditioning with bright cyclic light leading to robust activation of signal transducer and activator of transcription-3 (STAT3) in a time-dependent manner. Further, blocking LIFR activation during preconditioning using a LIFR antagonist (LIF05) attenuated the induced STAT3 activation and also resulted in reduced preconditioning-induced protection of the retinal photoreceptors. These data demonstrate that LIFR and its ligands play an essential role in endogenous neuroprotective mechanisms triggered by preconditioning-induced stress. LIFR was newly found to be a suppressor of hepatocellular carcinoma (HCC), one of the world's top five causes of cancer-related deaths. |
| References |
|
Reviews
Write Your Own Review
Related Products
Check items to add to the cart or
