Human NBL1 ELISA Kit sinobiological KIT10169
$714.00
In stock
SKU
KIT10169
| Catalog No. | Size | Price (USD) |
| KIT10169-1 | 1 Kit (96 Tests) | $740.55 |
General Information
| Product name | Human NBL1 ELISA Kit |
| Specificity | This assay recognizes both recombinant and natural Human DAN. |
| Conjugate | HRP |
| Shipping | This ELISA Kit is shipped at ambient temperature. |
| Storage | Unopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA |
| Assay type | Solid Phase Sandwich ELISA (quantitative) |
| Sample type | Serum |
| Sensitivity | 11.2 pg/mL |
| Assay range | 46.88-3000 pg/mL |
| Materials provided | 1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Color Reagent A 7. Color Reagent B 8. Stop Solution |
| Product overview | This Human NBL1 ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Human NBL1 protein in Serum . It contains recombinant Human NBL1, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use. |
| Interference | Preparations of BMP2 at 30 ng/mL in a mid-range recombinant human DAN control were assayed for interference. No significant interference was observed. |
Synonyms: D1S1733E ELISA Kit, Human; DAN ELISA Kit, Human; DAND1 ELISA Kit, Human; NB ELISA Kit, Human; NO3 ELISA Kit, Human
Image / Experimental Information
| Image 1 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 1 Alt Text | Human NBL1/DAND1 ELISA Kit Standard Curve 42 |
| Image 1 URL | Source image |
| Image 2 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 2 Alt Text | Human NBL1/DAND1 ELISA Kit Specificity 233 |
| Image 2 URL | Source image |
Background Information
| Full Name | neuroblastoma 1, DAN family BMP antagonist |
| Description | The Dan (Differential screening-selected gene aberrative in neuroblastoma, also known as N03) gene was first identified as the putative rat tumor suppressor gene and encodes a protein structurally related to Cerberus and Gremlin in the vertebrates. It is a founding member of the DAN family of secreted proteins, acts as an inhibitor of cell cycle progression, and is closely involved in retinoic acid-induced neuroblastoma differentiation. There are at least five mammalian protein members in the evolutionarily conserved Dan family including DAN, Gremlin/DRM, Cer1 (Cerberus-related), Dante, and PRDC (protein related to DAN and Cerberus), and share the C-terminal cystine-knot motif. As a secreted glycoprotein, DAN is a member of a class of glycoproteins shown to be secreted inhibitors of the transforming growth factor-beta (TGF-beta) and bone morphogenic protein pathways. It binds to BMPs and preventing their interactions with signaling receptor complexes, and accordingly regulates the processes of embryonic development and tissue differentiation. DAN gene product may have an important role in the regulation of the entry of cells into the S phase. Besides, the DAN gene product possesses an ability to revert phenotypes of transformed rat fibroblasts and represents a candidate tumor suppressor gene for neuroblastoma. |
| References |
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