| Catalog No. | Size | Price (USD) |
| 10108-H05H-1 | 1 mg | $4,678.82 |
| 10108-H05H-10 | 10 µg | $342.14 |
| 10108-H05H-20 | 20 µg | $419.15 |
| 10108-H05H-50 | 50 µg | $669.46 |
| 10108-H05H-100 | 100 µg | $1,073.80 |
General Information
| Formulation | Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Shipping | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
| Stability & Storage | Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Reconstitution | To find reconstitution info, click on 'COA' at the top of the page, enter the lot number and product size for the lot-specific COA. |
| Purity | ≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC. |
| Activity | 1.Measured by its ability to cleave a fluorogenic peptide substrate, McaYVADAPK (Dnp)OH, R&D Systems, Catalog # ES007. The specific activity is >500 pmols/min/ug(QC tested). 2.Immobilized Recombinant Human ACE2 / Angiotensin-Converting Enzyme 2 Protein (Fc Tag) (Cat: 10108-H05H) at 1 μg/mL (100 μL/well) can bind Recombinant SARS-CoV-2 (2019-nCoV) Spike S1-Fc Recombinant Protein (Cat: 40591-V02H), the EC 50 is 18.1 ng/mL (Routinely tested). |
| Protein Construction | A DNA sequence encoding the human ACE2 (NP_068576.1) (Met1-Ser740) was expressed with the Fc region of mouse IgG1 at the C-terminus. |
| Accession# | NP_068576.1 |
| Expressed Host | HEK293 Cells |
| Species | Human |
| Predicted N Terminal | Gln 18 |
| Molecule Mass | The recombinant human ACE2 consists 957 amino acids and predicts a molecular mass of 110 kDa. |
Synonyms: ACEH Protein, Human; UNQ868/PRO1885 Protein, Human
Image / Experimental Information
| Image 1 Alt Text | Human ACE2 / Angiotensin-Converting Enzyme 2 Protein 8399 |
| Image 1 URL | Source image |
| Image 2 Alt Text | Human ACE2 Protein 42939 |
| Image 2 URL | Source image |
| Image 3 Alt Text | Human ACE2 Protein 47422 |
| Image 3 URL | Source image |
Background Information
| Full Name | angiotensin I converting enzyme 2 |
| Description | Angiotensin-converting enzyme 2 (ACE2), a first homolog of ACE, regulates the renin angiotensin system (RAS) by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular, renal and respiratory systems. ACE2 also has an important role in blood pressure control. This enzyme, an homolog of ACE, hydrolyzes angiotensin (Ang) I to produce Ang-(1-9), which is subsequently converted into Ang-(1-7) by a neutral endopeptidase and ACE. ACE2 releases Ang-(1-7) more efficiently than its catalysis of Ang-(1-9) by cleavage of Pro(7)-Phe(8) bound in Ang II. Thus, the major biologically active product of ACE2 is Ang-(1-7), which is considered to be a beneficial peptide of the RAS cascade in the cardiovascular system. A physiological role for ACE2 has been implicated in hypertension, cardiac function, heart function and diabetes, and as a receptor of the severe acute respiratory syndrome coronavirus. In the acute respiratory distress syndrome (ARDS), ACE, AngII, and AT1R promote the disease pathogenesis, whereas ACE2 and the AT2R protect from ARDS. Importantly, ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in severe acute respiratory syndrome (SARS) pathogenesis. Furthermore, the recent explosion of research into the ACE2 homolog, collectrin, has revealed a new physiological function of ACE2 as an amino acid transporter, which explains the pathogenic role of gene mutations in Hartnup disorder. This review summarizes and discusses the recently unveiled roles for ACE2 in disease pathogenesis. |
| References |
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Utz"],"journal":"Nature Communications","date":"2021-09-14","pmid":"34521836","doi":"10.1038/s41467-021-25509-3"},{"title":"A universal bacteriophage T4 nanoparticle platform to design multiplex SARS-CoV-2 vaccine candidates by CRISPR engineering","authors":["Jingen Zhu","Neeti Ananthaswamy","...","Venigalla B. Rao"],"journal":"Science Advances","date":"2021-09-01","pmid":"34516878","doi":"10.1126/sciadv.abh1547"},{"title":"Identification of lectin receptors for conserved SARS‐CoV‐2 glycosylation sites","authors":["David Hoffmann","Stefan Mereiter","...","Josef M Penninger"],"journal":"The EMBO Journal","date":"2021-08-23","pmid":"34375000","doi":"10.15252/embj.2021108375"},{"title":"Full-Length Recombinant hSP-D Binds and Inhibits SARS-CoV-2","authors":["Raquel Arroyo","Shawn N. 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Dimitrov"],"journal":"STAR Protocols","date":"2021-05-29","pmid":"34095859","doi":"10.1016/j.xpro.2021.100617"},{"title":"SARS-CoV-2 B.1.1.7 and B.1.351 spike variants bind human ACE2 with increased affinity","authors":["Muthukumar Ramanathan","Ian D Ferguson","...","Paul A Khavari"],"journal":"The Lancet. Infectious Diseases","date":"2021-05-19","pmid":"34022142","doi":"10.1016/S1473-3099(21)00262-0"},{"title":"Small-Molecule Inhibitors of the Coronavirus Spike: ACE2 Protein–Protein Interaction as Blockers of Viral Attachment and Entry for SARS-CoV-2","authors":["Damir Bojadzic","Oscar Alcazar","...","Peter Buchwald"],"journal":"ACS Infectious Diseases","date":"2021-05-12","pmid":"33979123","doi":"10.1021/acsinfecdis.1c00070"},{"title":"Drug development of an affinity enhanced, broadly neutralizing heavy chain-only antibody that restricts SARS-CoV-2 in rodents","authors":["Schepens Bert","van Schie Loes","...","Saelens Xavier"],"journal":"bioRxiv","date":"2021-03-18","pmid":"","doi":"10.1101/2021.03.08.433449"},{"title":"Aptamer Blocking Strategy Inhibits SARS‐CoV‐2 Virus Infection","authors":["Miao Sun","Siwen Liu","...","Chaoyong Yang"],"journal":"Angewandte Chemie (International Ed. in English)","date":"2021-03-10","pmid":"33561300","doi":"10.1002/anie.202100225"},{"title":"Methylene Blue Inhibits the SARS-CoV-2 Spike–ACE2 Protein-Protein Interaction–a Mechanism that can Contribute to its Antiviral Activity Against COVID-19","authors":["Damir Bojadzic","Oscar Alcazar","Peter Buchwald"],"journal":"Frontiers in Pharmacology","date":"2021-01-13","pmid":"33519460","doi":"10.3389/fphar.2020.600372"},{"title":"Small-Molecule In Vitro Inhibitors of the Coronavirus Spike – ACE2 Protein-Protein Interaction as Blockers of Viral Attachment and Entry for SARS-CoV-2","authors":["Bojadzic Damir","Alcazar Oscar","...","Buchwald Peter"],"journal":"bioRxiv","date":"2020-10-22","pmid":"","doi":"10.1101/2020.10.22.351056"},{"title":"A novel rapid detection for SARS-CoV-2 spike 1 antigens using human angiotensin converting enzyme 2 (ACE2)","authors":["Jong-Hwan Lee","Minsuk Choi","...","Hong Gi Kim"],"journal":"Biosensors & bioelectronics","date":"2020-10-15","pmid":"33099241","doi":"10.1016/j.bios.2020.112715"},{"title":"A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers","authors":["Ran Liu","Lei He","...","Jingjing Zhang"],"journal":"Chemical Science","date":"2020-10-12","pmid":"34123223","doi":"10.1039/d0sc03920a"},{"title":"High Potency of a Bivalent Human V H Domain in SARS-CoV-2 Animal Models","authors":["Wei Li","Alexandra Schäfer","...","Dimiter S. Dimitrov"],"journal":"Cell","date":"2020-09-04","pmid":"32941803","doi":"10.1016/j.cell.2020.09.007"},{"title":"Methylene Blue Inhibits In Vitro the SARS-CoV-2 Spike – ACE2 Protein-Protein Interaction – A Mechanism That Can Contribute to Its Antiviral Activity Against COVID-19","authors":["Bojadzic Damir","Alcazar Oscar","Buchwald Peter"],"journal":"bioRxiv","date":"2020-08-31","pmid":"","doi":"10.1101/2020.08.29.273441"},{"title":"SARS-CoV-2 Assays To Detect Functional Antibody Responses That Block ACE2 Recognition in Vaccinated Animals and Infected Patients","authors":["Susanne N. Walker","Neethu Chokkalingam","...","Alexander J. McAdam"],"journal":"Journal of Clinical Microbiology","date":"2020-08-27","pmid":"32855181","doi":"10.1128/JCM.01533-20"},{"title":"Bcr-Abl tyrosine kinase inhibitor imatinib as a potential drug for COVID-19","authors":["Mulgaonkar Nirmitee","Wang Haoqi","...","Ruzek Daniel"],"journal":"bioRxiv","date":"2020-08-18","pmid":"","doi":"10.1101/2020.06.18.158196"},{"title":"Detection of SARS-CoV-2 neutralizing antibodies with a cell-free PCR assay","authors":["Danh Kenneth","Karp Donna Grace","...","Tsai Cheng-ting"],"journal":"medRxiv","date":"2020-06-02","pmid":"","doi":""},{"title":"Isolation of and Characterization of Neutralizing Antibodies to Covid-19 from a Large Human Naïve scFv Phage Display Library","authors":["Yuan Andy Q.","Zhao Likun","...","Xue Xiaoying"],"journal":"bioRxiv","date":"2020-05-19","pmid":"","doi":"10.1101/2020.05.19.104281"}]
