| Catalog No. | Size | Price (USD) |
| 10818-H08H-10 | 10 µg | $174.77 |
| 10818-H08H-20 | 20 µg | $476.92 |
| 10818-H08H-50 | 50 µg | $515.43 |
| 10818-H08H-500 | 500 µg | $1,611.45 |
General Information
| Formulation | Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Shipping | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
| Stability & Storage | Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Reconstitution | To find reconstitution info, click on 'COA' at the top of the page, enter the lot number and product size for the lot-specific COA. |
| Purity | > 97 % as determined by SDS-PAGE.≥ 95 % as determined by SEC-HPLC. |
| Activity | 1. Measured by its ability to convert the substrate nicotinamide guanine dinucleotide (NGD+) to cyclic GDPribose.The specific activity is > 2,500 pmoles/min/μg. 2. Measured by its binding ability in a functional ELISA. Immobilized Human CD38 His (Cat:10818-H08H) at 2 μg/ml (100 μl/well) can bind Mouse Anti-CD38 Antibody (Cat:10818-MM03), the EC 50 of Mouse Anti-CD38 Antibody is 30-120 ng/mL. 3.Captured 68048-H001（Daratumumab) on anti-human IgG Fc via CM5 Chip can bind CD38 (Cat.No.10818-H08H) with an affinity constant of 5.429 nM as determined in a SPR assay (Biacore T200)(Routinely tested). 4.Daratumumab captured on Protein A chip can bind Recombinant Human CD38 Protein, His Tag (Cat. No. 10818-H08H) with an affinity constant of 51.760 nM as determined in an SPR assay (Biacore T200) (Routinely tested). |
| Protein Construction | A DNA sequence encoding the extracellular domain of human CD38 (NP_001766.2) (Val 43-Ile 300) with a C-terminal polyhistidine tag was expressed. |
| Accession# | NP_001766.2 |
| Expressed Host | HEK293 Cells |
| Species | Human |
| Predicted N Terminal | Val 43 |
| Molecule Mass | The secreted recombinant human CD38 comprises 269 amino acids with a predicted molecular mass of 31.3 kDa. As a result of glycosylation, rhCD38 migrates as an approximately 43-45 kDa band in SDS-PAGE under reducing conditions. |
Synonyms: ADPRC 1 Protein, Human; ADPRC1 Protein, Human; cADPR1 Protein, Human
Image / Experimental Information
| Image 1 Alt Text | Human CD38/ADPRC1 Protein 9137 |
| Image 1 URL | Source image |
| Image 2 Alt Text | Human CD38 Protein 30053 |
| Image 2 URL | Source image |
| Image 3 Alt Text | Human CD38 Protein 35916 |
| Image 3 URL | Source image |
| Image 4 Alt Text | Human CD38 Protein 36048 |
| Image 4 URL | Source image |
| Image 5 Alt Text | Human CD38 Protein 42851 |
| Image 5 URL | Source image |
Background Information
| Full Name | CD38 molecule |
| Description | The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 38 (CD38), also known as ADP-ribosyl cyclase, is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4 , CD8 , B and natural killer cells. It shares several characteristics with ADP-ribosyl cyclase 2 CD157. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD to ADP-ribose. It also functions in cell adhesion, signal transduction and calcium signaling. CD38 has been used as a prognostic marker in leukemia. It can also be used to identify plasma cells. |
| Research Areas |
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| References |
|
title: Compounds and their uses as CD38 inhibitors
authors: Jianbei Xi; Guohuang Fan; ...; Kin Chiu Fong
date: 2026-07-14
cited_by_count: 0
techniques: Activity Assay; Control
bioz_score: 94
title: Enhancing CAR- and TCR-mediated targeting of cancer via an immune synapse-stabilizing receptor.
authors: Chiou-Tsun Tsai; Jorge Ibanez-Vega; ...; Maksim Mamonkin
journal: Nature Communications
date: 2026-02-04
pmid: 41639073
doi: 10.1038/s41467-025-65897-4
cited_by_count: 0
techniques: Recombinant; Western Blot
bioz_score: 94
title: CD38 modulating antibody
authors: Anne Goubier; Josephine Salimu; ...; Bianka Prinz
date: 2025-05-20
cited_by_count: 0
techniques: Binding Assay; Clone Assay; Control; Expressing; In Vitro; Plasmid Preparation; Produced; Recombinant; Sequencing; Software; Transfection
bioz_score: 94
title: Synthetic GPCRs for programmable sensing and control of cell behaviour
authors: Nicholas A. Kalogriopoulos; Reika Tei; ...; Alice Ting
journal: Nature
date: 2024-12-04
pmid: 39633047
doi: 10.1038/s41586-024-08282-3
pmcid: 11666456
cited_by_count: 17
bioz_score: 94
title: Functional identification of soluble uric acid as an endogenous inhibitor of CD38
authors: Shijie Wen; Hiroshi Arakawa; ...; Ikumi Tamai
journal: eLife
date: 2024-11-11
doi: 10.7554/elife.96962
cited_by_count: 0
techniques: Activity Assay; Colorimetric Assay; Derivative Assay; Enzyme-linked Immunosorbent Assay; Giemsa Stain; Liquid Chromatography with Mass Spectroscopy; Recombinant; Software; Tandem Mass Spectroscopy
bioz_score: 94
title: Monoclonal antibody specifically binding human and monkey CD38 antigens, preparation method and use thereof
authors: Hongqun Hu; Xiaoqi Song; ...; Qunmin Zhou
date: 2024-05-07
cited_by_count: 0
techniques: Adjuvant; Enzyme-linked Immunosorbent Assay; Injection; Membrane; Recombinant
bioz_score: 94
title: CD38 restrains the activity of extracellular cGAMP in a model of multiple myeloma
authors: Lorenzo Cuollo; Samuele Di Cristofano; ...; Alessandra Soriani
journal: iScience
date: 2024-04-25
doi: 10.1016/j.isci.2024.109814
pmcid: 11091702
cited_by_count: 5
techniques: Binding Assay; Comparison; Competitive ELISA; Concentration Assay; Enzyme-linked Immunosorbent Assay; Expressing; Flow Cytometry; Fluorescence; Incubation; Inhibition; Isolation; Labeling; Plasmid Preparation; Protein Extraction; Real-time Polymerase Chain Reaction; Recombinant; Residue; Selection; Sequencing; Software; Staining; Standard Deviation; Titration; Transduction; Two Tailed Test; Virus; shRNA
bioz_score: 94
title: Discovery of a First-in-Class CD38 Inhibitor for the Treatment of Mitochondrial Myopathy.
authors: Yue Li; Yuanyuan Liu; ...; Guo-Huang Fan
journal: Journal of Medicinal Chemistry
date: 2023-09-28
pmid: 37696000
doi: 10.1021/acs.jmedchem.3c00391
cited_by_count: 8
techniques: Concentration Assay; Inhibition; Positive Control
bioz_score: 94
title: CD38-binding proteins comprising de-immunized Shiga toxin A subunit effectors
authors: Nibedita Chattopadhyay; Eric Poma; Erin Willert
date: 2023-08-01
cited_by_count: 0
techniques: Binding Assay; Concentration Assay; Derivative Assay; Enzyme-linked Immunosorbent Assay; Incubation; Recombinant; Software
bioz_score: 94
title: Trispecific binding proteins, methods, and uses thereof
authors: Christian Beil; Jochen Beninga; ...; Catherine Prades
date: 2023-03-28
cited_by_count: 0
techniques: Binding Assay; Injection; Recombinant
bioz_score: 94
title: TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity
authors: Harshad S. Ugamraj; Kevin Dang; ...; Pranjali Dalvi
journal: mAbs
date: 2022-07-22
pmid: 35867844
doi: 10.1080/19420862.2022.2095949
pmcid: 9311320
cited_by_count: 27
techniques: Activity Assay; Adjuvant; Binding Assay; Cloning; Comparison; Confocal Microscopy; Control; Enzyme Inhibition Assay; Expressing; Flow Cytometry; Fluorescence; Generated; In Silico; Incubation; Inhibition; Isolation; Lysis; Mutagenesis; Next-Generation Sequencing; Purification; Recombinant; Staining
bioz_score: 94
title: A Novel Human Antibody, HF, against HER2/erb-B2 Obtained by a Computer-Aided Antibody Design Method
authors: Chunxia Qiao; Ming Lv; ...; Jiannan Feng
journal: Engineering
date: 2021-09-01
doi: 10.1016/j.eng.2020.10.024
cited_by_count: 3
techniques: Activity Assay; Binding Assay; Concentration Assay; Control; Cytometry; In Vitro; In Vivo; Inhibition; Membrane; Microscopy; Modification; Mutagenesis; Transfection
bioz_score: 94
title: Avidity‐Based Selection of Tissue‐Specific CAR‐T Cells from a Combinatorial Cellular Library of CARs
authors: Peixiang Ma; Ping Ren; ...; Richard A. Lerner
journal: Advanced Science
date: 2021-01-29
pmid: 33747727
doi: 10.1002/advs.202003091
pmcid: 7967050
cited_by_count: 15
techniques: Activation Assay; Activity Assay; Binding Assay; Electroporation; Expressing; FACS; Fluorescence; Generated; In Vitro; In Vivo; Incubation; Isolation; Labeling; Luciferase; Lysis; Negative Control; Purification; Recombinant; Selection; Sequencing; Staining
bioz_score: 94
title: A Novel Approach to Remove Interference of Therapeutic Monoclonal Antibody with Serum Protein Electrophoresis
authors: Li Liu; Michael R. Shurin; Sarah E. Wheeler
journal: Clinical biochemistry
date: 2021-01-01
pmid: 31669513
doi: 10.1016/j.clinbiochem.2019.10.011
pmcid: 6928417
cited_by_count: 7
techniques: Acid Assay; Binding Assay; Concentration Assay; Electrophoresis; Magnetic Beads; Migration; Protein Concentration; Protein Electrophoresis
bioz_score: 94
title: A thin-film interferometry-based label-free immunoassay for the detection of daratumumab interference in serum protein electrophoresis.
authors: Yiqi Ruben Luo; Indrani Chakraborty; ...; Alan H B Wu
journal: Clinica chimica acta; international journal of clinical chemistry
date: 2020-10-01
pmid: 31883925
doi: 10.1016/j.cca.2019.12.019
cited_by_count: 5
techniques: Produced
bioz_score: 94
title: Complete Depletion of Daratumumab Interference in Serum Samples from Plasma Cell Myeloma Patients Improves the Detection of Endogenous M-Proteins in a Preliminary Study
authors: Hana Vakili; Sharon Koorse Germans; ...; Ibrahim A. Hashim
journal: Diagnostics
date: 2020-04-14
pmid: 32295157
doi: 10.3390/diagnostics10040219
pmcid: 7235820
cited_by_count: 2
techniques: Concentration Assay; In Vitro; Incubation; Magnetic Beads; Migration; Protein Concentration; Quantitation Assay; Recombinant; Titration
bioz_score: 94
title: Novel anti-CD38 humanized mAb SG003 possessed enhanced cytotoxicity in lymphoma than Daratumumab via antibody-dependent cell-mediated cytotoxicity
authors: Tao Yu; Chunxia Qiao; ...; Luqun Tang
journal: BMC biotechnology
date: 2019-05-22
pmid: 31118070
doi: 10.1186/s12896-019-0524-8
pmcid: 6530185
cited_by_count: 1
techniques: Activity Assay; Binding Assay; Enzyme-linked Immunosorbent Assay; Expressing; Flow Cytometry; In Vivo; Injection; Luciferase; Modification; Negative Control
bioz_score: 94
title: Targeting Multiple Myeloma with AMG 424, a Novel Anti-CD38/CD3 Bispecific T-cell–recruiting Antibody Optimized for Cytotoxicity and Cytokine Release
authors: Christina L. Zuch de Zafra; Flordeliza Fajardo; ...; Olivier Nolan-Stevaux
journal: Clinical Cancer Research
date: 2019-03-27
doi: 10.1158/1078-0432.ccr-18-2752
cited_by_count: 86
techniques: Flow Cytometry; Luciferase; Recombinant
bioz_score: 94
