| Catalog No. | Size | Price (USD) |
| GMP-10360-HNAE-1 | 1 mg | $3,655.38 |
| GMP-10360-HNAE-10 | 10 µg | $145.15 |
| GMP-10360-HNAE-100 | 100 µg | $752.40 |
General Information
| Formulation | Supplied as sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Endotoxin | < 10 EU per mg protein. |
| Shipping | Liquid. It is shipped out with blue ice. |
| Stability & Storage | Samples are stable for up to thirty-six months from date of receipt at -20℃ to -80℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Reconstitution | To find reconstitution info, click on 'COA' at the top of the page, enter the lot number and product size for the lot-specific COA. |
| Purity | ≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC. |
| Activity | Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The ED 50 for this effect is typically 3-12 ng/mL. |
| Protein Construction | A DNA sequence encoding the human IL15 (NP_000576.1) (Asn49-Ser162) was expressed. |
| Accession# | NP_000576.1 |
| Expressed Host | E. coli |
| Species | Human |
| Predicted N Terminal | Met |
| Molecule Mass | The recombinant human IL15 consists of 115 amino acids and predicts a molecular mass of 12.91 kDa. |
Synonyms: IL-15 Protein, Human; MGC9721 Protein, Human
Image / Experimental Information
| Image 1 Alt Text | Human IL-1 beta Protein 34216 |
| Image 1 URL | Source image |
| Image 2 Alt Text | Human GM-CSF/CSF2 Protein 36148 |
| Image 2 URL | Source image |
| Image 3 Alt Text | Human IL-15 Protein 34441 |
| Image 3 URL | Source image |
| Image 4 Alt Text | Human IL-15 Protein 34445 |
| Image 4 URL | Source image |
| Image 5 Alt Text | Human IL-15 Protein 34447 |
| Image 5 URL | Source image |
Background Information
| Full Name | interleukin 15 |
| Description | The protein encoded by the IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietic receptor subunits and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively, spliced transcript variants of this gene have been reported. |
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| Tags |
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| References |
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title: International multisite implementation of distributed cell-free protein biomanufacturing to advance health and research equity
authors: Severino Jefferson Ribeiro da Silva; Quinn Matthews; ...; Keith Pardee
journal: Science Advances
date: 2026-05-29
pmid: 42213847
doi: 10.1126/sciadv.aeb7039
cited_by_count: 0
techniques: Biomarker Discovery; Derivative Assay; Expressing; In Vitro; Molecular Weight; Produced; Proliferation Assay; Recombinant; Selection; Viability Assay; Western Blot
bioz_score: 94
title: Targeting ROR1 with humanized antibody drug conjugates and cytokine fusion proteins for cancer therapy
authors: Beixue Li; Rui Jin; ...; Jing Liu
journal: iScience
date: 2026-05-15
pmid: 42023144
doi: 10.1016/j.isci.2026.115578
cited_by_count: 0
techniques: Recombinant
bioz_score: 94
title: International Multi-site Implementation of Local Cell-Free Protein Biomanufacturing to Advance Health and Research Equity
authors: Ribeiro da Silva Severino Jefferson; Matthews Quinn; ...; Pardee Keith
journal: medRxiv
date: 2025-07-27
doi: 10.1101/2025.07.25.25332228
cited_by_count: 0
techniques: Recombinant; Viability Assay
bioz_score: 94
title: Heterologous survey of 130 DNA transposons in human cells highlights their functional divergence and expands the genome engineering toolbox.
authors: Tongtong Zhang; Shengjun Tan; ...; Yong E Zhang
journal: Cell
date: 2024-07-12
pmid: 38843831
doi: 10.1016/j.cell.2024.05.007
cited_by_count: 10
techniques: Conjugation Assay; Construct; Lysis; Recombinant; Staining; Virus
bioz_score: 94
title: Targeted LNPs deliver mRNA encoding IL-15 superagonists to balance efficacy and toxicity in cancer therapy
authors: Yu Juntao; Li Qian; ...; Hu Rongkuan
journal: bioRxiv
date: 2024-01-12
doi: 10.1101/2024.01.11.575299
cited_by_count: 0
techniques: Cell Viability Assay; Enzyme-linked Immunosorbent Assay; Immunohistochemistry; Isolation; Luciferase; Purification; Recombinant
bioz_score: 93
title: An intranasally administrated SARS-CoV-2 beta variant subunit booster vaccine prevents beta variant replication in rhesus macaques.
authors: Yongjun Sui; Jianping Li; ...; Jay A Berzofsky
journal: PNAS Nexus
date: 2022-07-01
pmid: 35873792
doi: 10.1093/pnasnexus/pgac091
cited_by_count: 10
techniques: Adjuvant; Recombinant; Variant Assay
bioz_score: 94
title: Bottom-up assembly of target-specific cytotoxic synthetic cells.
authors: Jochen Estebano Hernandez Bücher; Oskar Staufer; ...; Joachim Pius Spatz
journal: Biomaterials
date: 2022-06-01
pmid: 35500392
doi: 10.1016/j.biomaterials.2022.121522
cited_by_count: 29
techniques: Recombinant
bioz_score: 94
title: An intranasally administrated SARS-CoV-2 beta variant subunit booster vaccine prevents beta variant viral replication in rhesus macaques
authors: Sui Yongjun; Li Jianping; ...; Berzofsky Jay A.
journal: bioRxiv
date: 2021-10-20
doi: 10.1101/2021.10.19.464990
cited_by_count: 0
techniques: Recombinant; Variant Assay
bioz_score: 94
title: Optimization of canine CD20 chimeric antigen receptor T cell manufacturing and in vitro cytotoxic activity against B-cell lymphoma.
authors: Osamu Sakai; Masaya Igase; Takuya Mizuno
journal: Veterinary and comparative oncology
date: 2021-09-08
pmid: 32329214
doi: 10.1111/vco.12602
cited_by_count: 21
techniques: Recombinant
bioz_score: 94
title: Protection against SARS-CoV-2 infection by a mucosal vaccine in rhesus macaques
authors: Yongjun Sui; Jianping Li; ...; Jay A. Berzofsky
journal: JCI insight
date: 2021-04-28
pmid: 33908897
doi: 10.1172/jci.insight.148494
pmcid: 8262352
cited_by_count: 67
techniques: Recombinant
bioz_score: 94
title: NOTCH-induced rerouting of endosomal trafficking disables regulatory T cells in vasculitis
authors: Ke Jin; Zhenke Wen; ...; Cornelia M. Weyand
journal: Journal of Clinical Investigation
date: 2021-01-04
doi: 10.1172/jci136042
cited_by_count: 0
techniques: Cell Isolation; Control; Incubation; Isolation; Purification; Recombinant
bioz_score: 93
title: A VEGFR2–MICA bispecific antibody activates tumor-infiltrating lymphocytes and exhibits potent anti-tumor efficacy in mice
authors: Yao Xu; Xinrong Zhang; ...; Juan Zhang
journal: Cancer Immunology, Immunotherapy : CII
date: 2019-09-01
pmid: 31428800
pmcid: 11028065
cited_by_count: 8
techniques: Cell Culture; Concentration Assay; Expressing; Flow Cytometry; Incubation; Isolation; Lysis; Recombinant
bioz_score: 94
