| Catalog No. | Size | Price (USD) |
| 16742-H02H-1 | 1 mg | $4,982.45 |
| 16742-H02H-20 | 20 µg | $342.14 |
| 16742-H02H-100 | 100 µg | $765.73 |
General Information
| Formulation | Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Shipping | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
| Stability & Storage | Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Reconstitution | To find reconstitution info, click on 'COA' at the top of the page, enter the lot number and product size for the lot-specific COA. |
| Purity | ≥ 95 % as determined by SDS-PAGE. ≥ 85 % as determined by SEC-HPLC. |
| Activity | Testing in progress |
| Protein Construction | A DNA sequence encoding the human LILRB4 (NP_001265356.2) (Met1-His257) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Accession# | NP_001265356.2 |
| Expressed Host | HEK293 Cells |
| Species | Human |
| Predicted N Terminal | Met 21 |
| Molecule Mass | The recombinant human LILRB4 consists of 475 amino acids and predicts a molecular mass of 52.8 kDa. As a result of glycosylation, it migrates as an approximately 61.8 KDa band in SDS-PAGE under reducing conditions. |
Synonyms: B4 Protein, Human; CD85K Protein, Human; HM18 Protein, Human; ILT-3 Protein, Human; ILT3 Protein, Human; LIR-5 Protein, Human; LIR5 Protein, Human
Image / Experimental Information
| Image 1 Alt Text | Human LILRB4/CD85k/ILT3 Protein 6280 |
| Image 1 URL | Source image |
| Image 2 Alt Text | Human ILT3 Protein 37906 |
| Image 2 URL | Source image |
Background Information
| Full Name | leukocyte immunoglobulin like receptor B4 |
| Description | LILRB4 (Leukocyte Immunoglobulin Like Receptor B4) is a Protein Coding gene. This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. LILRB4 is believed to down-regulate activation signals mediated by non-receptor tyrosine kinase cascades through the recruitment of SHP-1. LILRB4 is associated with the pathological processes of various inflammatory diseases. The LILRB4 is a central inhibitory receptor in Uterine dendritic cells (uDCs) that plays essential immune-regulatory roles at the maternal-fetal interface. |
title: Direct Small Molecule Modulation of LILRB4 (ILT3) Restores Antitumor Immunity In Vivo and in Patient-Derived Cells.
authors: Somaya A Abdel-Rahman; Zamara Mariam; ...; Moustafa T Gabr
journal: ACS chemical biology
date: 2026-07-26
pmid: 42503804
doi: 10.1021/acschembio.6c00486
cited_by_count: 0
techniques: Competitive Binding Assay; Incubation; Recombinant; Serial Dilution
bioz_score: 94
title: Direct Small Molecule Modulation of LILRB4 (ILT3) Restores Anti-Tumor Immunity In Vivo and in Patient-Derived Cells
authors: Abdel-Rahman Somaya A.; Mariam Zamara; ...; Gabr Moustafa T.
journal: bioRxiv
date: 2026-06-11
doi: 10.64898/2026.06.10.731269
cited_by_count: 0
techniques: Competitive Binding Assay; Incubation; Recombinant; Serial Dilution
bioz_score: 94
title: Development of a high-throughput TR-FRET assay for identification of small molecule inhibitors of the LILRB4 (ILT3)-SCG2 immune checkpoint interaction.
authors: Somaya A Abdel-Rahman; Moustafa T Gabr
journal: SLAS discovery : advancing life sciences R & D
date: 2026-06-10
pmid: 42269774
doi: 10.1016/j.slasd.2026.100316
cited_by_count: 0
techniques: Biomarker Discovery; Incubation; Recombinant; Titration
bioz_score: 94
title: Targeting the Myeloid Immune Checkpoint ILT3 (LILRB4) with Small Molecules Enables Reprogramming of Suppressive Tumor Immunity
authors: Abdel-Rahman Somaya A.; Monari Antonio; ...; Gabr Moustafa T.
journal: bioRxiv
date: 2026-06-09
doi: 10.64898/2026.06.05.730341
cited_by_count: 0
techniques: Competitive Binding Assay; Incubation; Recombinant; Serial Dilution
bioz_score: 94
title: Secretogranin 2 binds LILRB4 resulting in immunosuppression
authors: Xing Yang; Ryan Huang; ...; Cheng Cheng Zhang
journal: Nature immunology
date: 2025-09-01
pmid: 40707822
doi: 10.1038/s41590-025-02233-4
cited_by_count: 4
techniques: Incubation; Transfection
bioz_score: 99
title: ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion.
authors: Shouyan Deng; Yibo Zhang; ...; Jie Xu
journal: Cell
date: 2024-04-26
pmid: 38614099
doi: 10.1016/j.cell.2024.03.019
cited_by_count: 35
techniques: Recombinant
bioz_score: 94
title: Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors
authors: Yiting Wang; Yufan Sun; ...; Jie Xu
journal: Cell Reports Medicine
date: 2024-01-16
pmid: 38232701
doi: 10.1016/j.xcrm.2023.101374
pmcid: 10829871
cited_by_count: 16
techniques: Activation Assay; Bicinchoninic Acid Protein Assay; Binding Assay; Blocking Assay; Cell Culture; Cell Function Assay; Clone Assay; Concentration Assay; Derivative Assay; Enzyme-linked Immunosorbent Assay; Ex Vivo; Expressing; Extraction; Flow Cytometry; Fluorescence; Immunohistochemistry; In Vivo; Incubation; Inhibition; Labeling; Lysis; Marker; Membrane; Microarray; Microscopy; Negative Control; Over Expression; Plasmid Preparation; Proliferation Assay; RNA Expression; RNA Sequencing Assay; Recombinant; Selection; Sequencing; Serial Dilution; Silver Staining; Software; Staining; Transfection; shRNA
bioz_score: 93
title: Galectin-8 is a major ligand of LILRB4 prompting MDSC functions in the tumor microenvironment
authors: Wang Yiting; Sun Yufan; ...; Xu Jie
journal: bioRxiv
date: 2022-07-27
doi: 10.1101/2022.07.27.501694
cited_by_count: 0
techniques: Activation Assay; Binding Assay; Concentration Assay; Enzyme-linked Immunosorbent Assay; Ex Vivo; Flow Cytometry; Immunofluorescence; In Vivo; Incubation; Protein Extraction; Recombinant; Staining; Transplantation Assay
bioz_score: 94
title: The ITPRIPL1- CD3ε axis: a novel immune checkpoint controlling T cells activation
authors: Deng Shouyan; Wang Yiting; ...; Xu Jie
journal: bioRxiv
date: 2022-03-01
doi: 10.1101/2022.02.25.481189
cited_by_count: 0
techniques: Recombinant
bioz_score: 94
title: Disrupting LILRB4/APOE interaction by an efficacious humanized antibody reverses T-cell suppression and blocks AML development
authors: Xun Gui; Mi Deng; ...; Zhiqiang An
journal: Cancer Immunology Research
date: 2020-02-01
pmid: 31213474
doi: 10.1158/2326-6066.CIR-19-0036
pmcid: 6677629
cited_by_count: 49
techniques: Ab Array; Binding Assay; Blocking Assay; Cell Culture; Cell Isolation; Clone Assay; Co-culture Assay; Derivative Assay; Enzyme-linked Immunosorbent Assay; Expressing; Flow Cytometry; Functional Assay; Imaging; Incubation; Indirect ELISA; Injection; Inverted Microscopy; Irradiation; Isolation; Labeling; Lactate Dehydrogenase Assay; Luciferase; Migration; Negative Control; Produced; Purification; Quantitation Assay; Recombinant; Reporter Assay; Sequencing; Staining; Transplantation Assay
bioz_score: 93
title: ILT3.Fc-CD166 Interaction Induces Inactivation of p70 S6 Kinase and Inhibits Tumor Cell Growth.
authors: Zheng Xu; Chih-Chao Chang; ...; Nicole Suciu-Foca
journal: Journal of Immunology (Baltimore, Md. : 1950)
date: 2018-10-01
pmid: 29263213
doi: 10.4049/jimmunol.1700553
cited_by_count: 34
techniques: Concentration Assay; Injection; Labeling; Recombinant
bioz_score: 94
