Anti-CRELD1 Antibody, Rabbit Polyclonal sinobiological 13411-RP01

$143.00
In stock
SKU
13411-RP01
Catalog No.SizePrice (USD)
13411-RP01-100100 µL$147.96
13411-RP01-200200 µL$251.64
13411-RP01-400400 µL$355.32

General Information

Product nameAnti-CRELD1 Antibody, Rabbit Polyclonal
Validated applicationsELISA (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman CRELD1
ImmunogenRecombinant Human CRELD1 protein (Catalog#13411-H08H)
PreparationProduced in rabbits immunized with purified, recombinant Human CRELD1 (rh CRELD1; Catalog#13411-H08H; NP_001070883.1; Met1-Glu362). Total IgG was purified by Protein A affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A
Formulation0.2 μm filtered solution in PBS
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-AVSD2 Antibody; Anti-CIRRIN Antibody; Anti-JELANS Antibody; Anti-UNQ188/PRO214 Antibody

Background Information

Full Namecysteine-rich with EGF-like domains 1
DescriptionCRELD1 is a transmembrane glycoprotein. Epidermal growth factor(EGF)­like domain exists in CRELD1. EGF-like repeats are a class of cysteine-rich domains that mediate interactions between proteins of diverse function. EGF domains are found in proteins that are either completely secreted or have transmembrane regions that tether the protein to the cell surface. CRELD1 contains a 333 amino acid acid (aa) extracellular domain (ECD), two tandem transmembrane segments, and a second ECD of 15 aa. Defects in CRELD1 may cause susceptibility to atrioventricular septal defect type 2 which results in a persistent common atrioventricular canal.
References
  1. Robinson SW, et al . (2003) Missense Mutations in CRELD1 Are Associated with Cardiac Atrioventricular Septal Defects. Am J Hum Genet. 72(4):1047-52.
  2. Zatyka M, et al . (2005) Analysis of CRELD1 as a candidate 3p25 atrioventicular septal defect locus (AVSD2). Clin Genet. 67(6):526-8.
  3. Stelzl U, et al . (2005) A human protein-protein interaction network: a resource for annotating the proteome. Cell. 122(6):957-68.

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