| Catalog No. | Size | Price (USD) |
| 10395-R508-200 | 200 µg | $296.22 |
| 10395-R508-500 | 500 µg | $444.33 |
General Information
| Product name | IL6 / IL-6 Neutralizing Antibody |
| Validated applications | Neutralization |
| Species reactivity | Reacts with: Human |
| Specificity | Human IL-6 No cross-reactivity in ELISA with Rat IL6 (Catalog # 80076-RNAE) Mouse IL6 (Catalog # 50136-MNAE) |
| Immunogen | Recombinant Human IL6 / IL-6 protein (Catalog#10395-HNAE) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human IL6 / IL-6 (rHuman IL6 / IL-6; Catalog#10395-HNAE; NP_000591.1; Val30-Met212) and was produced using recombinant antibody technology. |
| Source | Monoclonal Rabbit IgG Clone #R508 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Endotoxin | Please contact us for more information. |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-BSF-2 Antibody; Anti-BSF2 Antibody; Anti-CDF Antibody; Anti-HGF Antibody; Anti-HSF Antibody; Anti-IFN-beta-2 Antibody; Anti-IFNB2 Antibody; Anti-IL-6 Antibody
Image / Experimental Information
| Image 1 Description | The neutralization activity of IL-6 Neutralizing Antibody is measured by its ability to neutralize IL-6 induced proliferation in the T1165 mouse plasmacytoma cells. The IC50 is typically 80-320ng/mL in the presence of 10 ng/mL Recombinant Human IL-6. |
| Image 1 Alt Text | Human IL6/IL-6/Interleukin-6 Blocking/Neutralization (B/N) 5596 |
| Image 1 URL | Source image |
Background Information
| Full Name | interleukin 6 |
| Description | Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined as an essential role in directing the transition from innate to acquired immunity. |
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| References |
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title: Non-human vertebrate comprising human liver cells transplanted therein and method for producing the same
authors: Hiroshi Suemizu
date: 2026-06-02
cited_by_count: 0
techniques: Activity Assay; Clinical Proteomics; Concentration Assay; Enzyme-linked Immunosorbent Assay; Quantitation Assay; Saline; Sampling; Transplantation Assay
bioz_score: 94
title: Treponema pallidum protein Tp47 upregulates TNFAIP3 to promote microglia-mediated angiogenesis through the SOCS3/IL6 signaling pathway.
authors: Lin Xie; Feng-Qian Ma; ...; Li-Li Liu
journal: Microbial Pathogenesis
date: 2025-11-10
pmid: 41224156
doi: 10.1016/j.micpath.2025.108172
cited_by_count: 0
techniques: Fluorescence; Incubation; Microscopy; Software; Staining
bioz_score: 94
title: RAPPID-M: A Mix-and-Measure Bioluminescent Sandwich Immunoassay Based on Generic Antibody-Binding Protein M
authors: Anna Swietlikowska; Eva van Aalen; ...; Maarten Merkx
journal: ACS Sensors
date: 2025-10-10
pmid: 41070524
cited_by_count: 0
techniques: Binding Assay; Biomarker Discovery; SPR Assay; Software; Titration; Variant Assay
bioz_score: 94
title: Neutrophil profiling illuminates anti-tumor antigen-presenting potency.
authors: Yingcheng Wu; Jiaqiang Ma; ...; Qiang Gao
journal: Cell
date: 2024-03-18
pmid: 38447573
doi: 10.1016/j.cell.2024.02.005
cited_by_count: 196
techniques: Control; Derivative Assay; Expressing; Generated; Isolation; Microarray; Purification; Recombinant; Software
bioz_score: 94
title: IL6-STAT3-C/EBPβ-IL6 positive feedback loop in tumor-associated macrophages promotes the EMT and metastasis of lung adenocarcinoma.
authors: Zhengyang Hu; Qihai Sui; ...; Zhencong Chen
journal: Journal of Experimental & Clinical Cancer Research : CR
date: 2024-03-04
pmid: 38424624
doi: 10.1186/s13046-024-02989-x
cited_by_count: 115
techniques: Recombinant
bioz_score: 94
title: Integrated Bioluminescent Immunoassays for High-Throughput Sampling and Continuous Monitoring of Cytokines
authors: Eva A. van Aalen; Bas J. H. M. Rosier; ...; Maarten Merkx
journal: Analytical Chemistry
date: 2023-05-30
pmid: 37253113
pmcid: 10267889
cited_by_count: 6
bioz_score: 94
title: Lupus serum IgG induces microglia activation through Fc fragment dependent way and modulated by B-cell activating factor
authors: Chunshu Yang; Xiaoyu Hou; ...; Pingting Yang
journal: Journal of Translational Medicine
date: 2019-12-21
pmid: 31864410
doi: 10.1186/s12967-019-02175-0
pmcid: 6925475
cited_by_count: 18
techniques: Activation Assay; Expressing; Injection
bioz_score: 94
