| Catalog No. | Size | Price (USD) |
| 13059-MM24-1 | 1 mL | $1,377.43 |
| 13059-MM24-20 | 20 µL | $88.87 |
| 13059-MM24-50 | 50 µL | $147.96 |
| 13059-MM24-100 | 100 µL | $251.64 |
| 13059-MM24-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-IL-22 Antibody, Mouse Monoclonal |
| Validated applications | ELISA(Cap) (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human IL-22 |
| Immunogen | Recombinant Human IL22 / Interleukin 22 Protein (Catalog#13059-HNAE) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL22 / Interleukin 22 (rh IL22 / Interleukin 22; Catalog#13059-HNAE; NP_065386.1; Ala34-Ile179). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Source | Monoclonal Mouse IgG1 Clone #24 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-IL-21 Antibody; Anti-IL-22 Antibody; Anti-IL-D110 Antibody; Anti-IL-TIF Antibody; Anti-ILTIF Antibody; Anti-MGC79382 Antibody; Anti-MGC79384 Antibody; Anti-TIFa Antibody; Anti-TIFIL-23 Antibody; Anti-UNQ3099/PRO10096 Antibody; Anti-zcyto18 Antibody
Background Information
| Full Name | interleukin 22 |
| Description | IL22 is a member of a group of cytokines called the IL-1 family of IL-1 superfamily (including IL-19, IL-2, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. It shares the use of IL-1R2 in cell signaling with other members of this family, IL-1, IL-26, IL-28A/B, and IL-29. IL22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL22 along with IL-17 is rapidly produced by splenic LTi-like cells and can be also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive and innate immune systems. IL22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-1R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (SIL-22R1). IL22 and IL-1 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. IL22 can contribute to immune disease through the stimulation of inflammatory responses, S1s, and defensins. IL22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-1. In some contexts, the pro-inflammatory versus tissue-protective functions of IL22 are regulated by the often co-expressed cytokine IL-17A. |
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