| Catalog No. | Size | Price (USD) |
| 104712-T08-50 | 50 µL | $147.96 |
| 104712-T08-100 | 100 µL | $251.64 |
| 104712-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-keratin 76/KRT76 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human keratin 76/KRT76 |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Human KRT76 |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human KRT76, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-HUMCYT2A Antibody; Anti-KRT2B Antibody; Anti-KRT2P Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human KRT76 in human breast carcinoma with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human KRT76 Immunohistochemistry(IHC) 18280 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human KRT76 in human breast carcinoma with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human KRT76 Immunohistochemistry(IHC) 18281 |
| Image 2 URL | Source image |
Background Information
| Description | Keratin 76 (Krt76) is expressed in the differentiated epithelial layers of skin, oral cavity and squamous stomach. Krt76 downregulation in human oral squamous cell carcinomas (OSCC) correlates with poor prognosis. Krt76 is a type II intermediate filament protein expressed in the differentiating, non-proliferative layers of a subset of stratified epithelia in human and mouse. Krt76 is the most significantly downregulated gene encoding a structural protein in human oral squamous cell carcinoma (OSCC) and correlates strongly with poor prognosis. OSCC arises from the multilayered epithelial lining of the mouth and the lips. It involves mostly the tongue, but can also occur in the floor of the mouth, gingiva, lip, cheek and palate. In patients, KRT76 is detected in 100% of normal gingivobuccal epithelial biopsies, 44% of oral preneoplastic lesions and 35% of OSCC. |
| References |
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