| Catalog No. | Size | Price (USD) |
| 10231-R301-A-25 | 25 Tests | $103.68 |
| 10231-R301-A-100 | 100 Tests | $222.17 |
General Information
| Product name | Recombinant Anti-LDLR/LDL Receptor Antibody (APC), Rabbit Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human LDLR/LDL Receptor |
| Immunogen | Recombinant Human LDL Receptor / LDLR protein (Catalog#10231-H08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human LDL Receptor / LDLR (rh LDL Receptor / LDLR; Catalog#10231-H08H; NP_000518.1; Met 1-Arg 788) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Source | Monoclonal Rabbit IgG Clone #301 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Concentration | 5 μl/Test, 0.1 mg/ml |
| Conjugate | APC |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! |
Synonyms: Anti-FH Antibody; Anti-FHC Antibody; Anti-FHCL1 Antibody; Anti-LDLCQ2 Antibody
Image / Experimental Information
| Image 1 Description | Profile of anti-Human LDLR reactivity on A431 cells analyzed by flow cytometry. |
| Image 1 Alt Text | Human LDLR/LDL R/LDL Receptor Flow Cytometry (FC) 2694 |
| Image 1 URL | Source image |
Background Information
| Full Name | low density lipoprotein receptor |
| Description | LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL Receptor consists of 840 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. Low-density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. LDL Receptor is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants. |
| References |
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title: Development of a PCSK9-targeted nanoparticle vaccine to effectively decrease the hypercholesterolemia
authors: Qiannan Fang; Xinyu Lu; ...; Hui Zhang
journal: Cell Reports Medicine
date: 2024-06-18
pmid: 38897173
doi: 10.1016/j.xcrm.2024.101614
pmcid: 11228807
cited_by_count: 12
techniques: Adjuvant; Cell Stimulation; Enzyme-linked Immunosorbent Assay; Plasmid Preparation; Protein Extraction; RNA Extraction; Recombinant; Reverse Transcription; Software; Staining; Virus; Western Blot
bioz_score: 92
title: Downregulation of low-density lipoprotein receptor mRNA in lymphatic endothelial cells impairs lymphatic function through changes in intracellular lipids
authors: Laurent Vachon; Ali Smaani; ...; Catherine Martel
journal: Theranostics
date: 2022-01-01
doi: 10.7150/thno.58780
pmcid: 8771568
cited_by_count: 3
techniques: Cell Culture; Enzyme-linked Immunosorbent Assay; Expressing; Flow Cytometry; Fluorescence; Immunofluorescence; In Vivo Imaging; Incubation; Injection; Isolation; Negative Control; Positive Control; RNA Expression; Recombinant; Software; Staining; Transfection; Western Blot; shRNA
bioz_score: 92
title: Autophagy Blockade Limits HER2+ Breast Cancer Tumorigenesis by Perturbing HER2 Trafficking and Promoting Release Via Small Extracellular Vesicles.
authors: Mingang Hao; Syn Kok Yeo; ...; Jun-Lin Guan
journal: Developmental cell
date: 2021-08-27
pmid: 33472043
doi: 10.1016/j.devcel.2020.12.016
cited_by_count: 30
techniques: Activity Assay; Flow Cytometry; Imaging; Immunohistochemistry; Ubiquitin Proteomics; Western Blot
bioz_score: 92
