Anti-LILRA3 Antibody, Rabbit Polyclonal sinobiological 13549-RP01

$143.00
In stock
SKU
13549-RP01
Catalog No.SizePrice (USD)
13549-RP01-100100 µL$147.96
13549-RP01-200200 µL$251.64
13549-RP01-400400 µL$355.32

General Information

Product nameAnti-LILRA3 Antibody, Rabbit Polyclonal
Validated applicationsELISA (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman LILRA3
ImmunogenRecombinant Human ILT6 / LILRA3 protein (Catalog#13549-H08H)
PreparationProduced in rabbits immunized with purified, recombinant Human ILT6 / LILRA3 (rh LILRA3; Catalog#13549-H08H; AAH28208.1; Met1-Glu439). Total IgG was purified by Protein A affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A
Formulation0.2 μm filtered solution in PBS
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-CD85E Antibody; Anti-HM31 Antibody; Anti-HM43 Antibody; Anti-ILT-6 Antibody; Anti-ILT6 Antibody; Anti-LIR-4 Antibody; Anti-LIR4 Antibody

Background Information

Full Nameleukocyte immunoglobulin like receptor A3
DescriptionILT6, also known as LILRA3, belongs to the ILT family. In humans, the ILT gene family includes up to 11 members. The extracellular portion of all members includes at least two and usually four immunoglobulin domains. ILT-2 through 5 are all inhibitory members having variable numbers of cytoplasmic ITIM domains. ILT6 lacks a transmembrane domain. The function of ILT6 is currently unknown. however it is highly homologous to other LILR genes, and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the ILT6 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.
Research Areas
  • ITIM/ITAM Immunoreceptors and Related Molecules
References
  1. Wi?niewski A, et al. (2004) Distribution of LILRA3 (ILT6 / LILRA3/LIR4) deletion in psoriatic patients and healthy controls. Hum Immunol. 64(4):458-61.
  2. Norman PJ, et al. (2003) DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin-like receptor, LILRA3. Immunogenetics. 55(3):165-71.
  3. Cella M, et al. (1997) A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. J Exp Med. 185(10): 1743-51.

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