Phospho-Tau (Ser202) Antibody, Rabbit MAb sinobiological 110926-R0010

$100.00
In stock
SKU
110926-R0010
Catalog No.SizePrice (USD)
110926-R0010-2020 µL$103.53
110926-R0010-100100 µL$296.07

General Information

Product namePhospho-Tau (Ser202) Antibody, Rabbit MAb
Validated applicationsWB (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityPhospho-Tau (Ser202)
ImmunogenA synthetic phosphopeptide corresponding to residues around Ser202 of the Human Phospho-Tau
PreparationThis antibody was obtained from a rabbit immunized with a synthetic phosphopeptide corresponding to residues around Ser202 of the Human Phospho-Tau.
SourceMonoclonal Rabbit IgG Clone #0010
PurificationProtein A
Formulation10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-DDPAC Antibody; Anti-FLJ31424 Antibody; Anti-FTDP-17 Antibody; Anti-MAPTL Antibody; Anti-MGC138549 Antibody; Anti-MSTD Antibody; Anti-MTBT1 Antibody; Anti-MTBT2 Antibody; Anti-PPND Antibody; Anti-PPP1R103 Antibody; Anti-TAU Antibody; Anti-tau-40 Antibody; Anti-Tau-PHF6 Antibody

Image / Experimental Information

Image 1 DescriptionWestern blot analysis of extracts from mouse brain using Phospho-Tau (Ser202) rabbit monoclonal Antibody (Cat: 110926-R0010) at 1:20000 dilution (upper) or Anti-Tubulin Antibody, Mouse Monoclonal (Cat: 100109-MM05T) at 1:50000 dilution (lower).
Image 1 Alt TextHuman Tau Western blot (WB) 46794
Image 1 URLSource image
Image 2 DescriptionWestern blot analysis of extracts from mouse brain using Phospho-Tau (Ser202) rabbit monoclonal Antibody (Cat: 110926-R0010) at 1:20000 dilution (upper) or Anti-Tubulin Antibody, Mouse Monoclonal (Cat: 100109-MM05T) at 1:50000 dilution (lower).
Image 2 Alt TextHuman Tau Western blot (WB) 46795
Image 2 URLSource image

Background Information

Full Namemicrotubule-associated protein tau
DescriptionMAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. Other nervous system MAPs may perform similar functions, as suggested by tau knockout mice, who did not show abnormalities in brain development - possibly because of compensation in tau deficiency by other MAPs.
Related Pathways
  • AMPK Signaling Pathway
  • P38 MAPK Signaling Pathway
References
  1. Harada A, et al. (1994) Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature. 369(6480):488-91.
  2. Weingarten MD, et al. (1975) A protein factor essential for microtubule assembly. Proc Natl Acad Sci. 72(5):1858-62.
  3. Goedert M, et al. (1989) Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron. 3(4): 519-26.

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