| Catalog No. | Size | Price (USD) |
| 10759-T52-50 | 50 µL | $147.96 |
| 10759-T52-100 | 100 µL | $251.64 |
| 10759-T52-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-MICB Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol), IP (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human MICB |
| Immunogen | Recombinant Human MICB Protein (Catalog#10759-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human MICB (rh MICB; Catalog#10759-H08H; NP_005922.2; Met1-Gly298). MICB specific IgG was purified by Human MICB affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-PERB11.2 Antibody
Image / Experimental Information
| Image 1 Description | Anti-MICB rabbit polyclonal antibody at 1:500 dilution Lane A: Jurkat Whole Cell Lysate Lane B: MCF-7 Whole Cell Lysate Lane C: HepG2 Whole Cell Lysate Lane D: Daudi Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:43 kDa (We are unsure as to the identity of these extra bands.) |
| Image 1 Alt Text | Human MICB Western blot (WB) 35305 |
| Image 1 URL | Source image |
| Image 2 Description | Anti-MICB rabbit polyclonal antibody at 1:500 dilution Lane A: Jurkat Whole Cell Lysate Lane B: MCF-7 Whole Cell Lysate Lane C: HepG2 Whole Cell Lysate Lane D: Daudi Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:43 kDa (We are unsure as to the identity of these extra bands.) |
| Image 2 Alt Text | Human MICB Immunoprecipitation(IP) 35306 |
| Image 2 URL | Source image |
Background Information
| Full Name | MHC class I polypeptide-related sequence B |
| Description | MHC class I polypeptide-related sequence B, also known as MICB, is a heavily glycosylated protein serving as a ligand for the type II receptor NKG2D. MICB shares 85% amino acid identity with MICA, a closely related protein, both of which contain three extracellular immunoglobulin-like domains, but without the capacity to bind peptide or interact with beta-2-microglobulin. acting as a stress-induced self-antigen, binding of MICB to the NKG2D receptor activates the cytolytic response of natural killer (NK) cells, CD8+αβ T cells, and γδ T cells on which the receptor is expressed. MICA/B is minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B recognition thus is involved in tumor surveillance, viral infections, and autoimmune diseases. |
| References |
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