| Catalog No. | Size | Price (USD) |
| 203348-T08-50 | 50 µL | $147.96 |
| 203348-T08-100 | 100 µL | $251.64 |
| 203348-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-MIER2 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human MIER2 |
| Immunogen | E. coli-derived Human MIER2 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human MIER2 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-KIAA1193 Antibody; Anti-Mi-er2 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human MIER2 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human MIER2 Immunohistochemistry(IHC) 21958 |
| Image 1 URL | Source image |
Background Information
| Description | The MIER family consists of three related genes encoding ELM2-SANT containing proteins. MIER1 is known to function in transcriptional repression through its ability to recruit HDAC1 and 2. MIER2 and MIER3 share a specific region of high homology, located upstream of the ELM2 domain (aa 98-149). This sequence is 87% identical in MIER2 and 3, but only 35% and 33%, respectively, to MIER1. MIER2 and MIER3 are mainly localized in the nucleus. MIER2, but not MIER3 complexes, have associated deacetylase activity. Only MIER2 can recruit HDAC1 and 2 activity, but this depends on cell type, and it does not do so as effectively as MIER1α. HDAC recruitment occurs through the ELM2 domain. |
| References |
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